Multiple complex developmental disorder (MCDD) manifests as early-onset impairment across different domains. Although it could appear as a transitional condition between autism and childhood-onset schizophrenia, interest in MCDD has progressively waned. This study attempts to discern MCDD current ...
the area on the fringe of autistic disorders, two categories emerged: Asperger's disorder (that was added to DSM IV 1994) and the group so-called multiplex developmental disorders (later renamed multiple complex developmental disorder to avoid confusion with MDD 鈥 "major depressive" disorder). ...
Dissociative identity disorder (DID), previously known as multiple personality disorder, is a complex psychological condition caused by many things. These include severe trauma during early childhood (usually extreme, repetitive physical, sexual, or emotional abuse). It's also known as split personality...
All six individuals had received speech therapy and two individuals had a formal diagnosis of expressive language disorder. Despite having shown prominent speech delays in infancy, for three of six individuals (aged 5–16 years) current speech is described as normal with full and complex sentences....
Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder. The present study tested the hypotheses that children with ADHD, partic... M Blomqvist,K Holmberg,F Lindblad,... - ...
1l). This transcript encodes an enzyme of the histone deacetylase complex which serves as an overarching regulator of epigenetic processes. Indeed, peripheral HDAC1 mRNA levels seem to be a more robust readout of epigenetic modifications in small sample sizes [36] as compared to specific ...
In addition to DNA methylation, posttranslational histone modifications also have an important role in regulation of chromatin structure and thereby in the transcriptional regulation of pathways that modulate aging [113,114,115]. Histone proteins form a complex with DNA to compile the nucleosomes consi...
include developmental and psychomotor delay, behavioral problems and autism spectrum disorder (ASD), structural brain abnormalitis, and distinct physical features [8]. The deletions and duplications overlapping the PAFAH1B1 and YWHAE genes located in the 17p13.3 region are associated with different ...
Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder Romain Icick Alexey Shadrin Ole A. Andreassen Nature Mental Health(2025) Exploring perceptions of genetic risk and the transmission of substance use disorders ...
(35.1%). Moreover, 59% of patients had a low performance on at least one neuropsychological test. The most impaired domains were complex attention (e.g., rapidly shifting attention between competing stimuli) (29.7%) and delayed recall of verbal and visual information (respectively, 18.9% and ...