These results extend our understanding of human SHBG gene transcription, and raise new and important questions regarding the role of novel alternatively spliced transcripts, their function in hormonally responsive tissues including the breast and prostate, and the role that aberrant SHBG gene expression ...
46,606, 54,946, 32,347, and 29,193 protein-coding genes were predicted within the genomes ofA. tanguticus,L. chinense,B. arborea, andM. caulescens, respectively (Table1, Supplementary Tables10–14, Supplementary Fig.4). The completeness of the genome annotation employing BUSCO across the ...
Cytokine genes are regulated by multiple regulatory elements that confer tissue-specific and activation-dependent expression. The cis-regulatory elements of the gene encoding IL-9, a cytokine that promotes allergy, autoimmune inflammation and tumor immun
In TCGA, six types of “omics” data have been collected on the same set of patients: DNA copy number variation, somatic mutation, mRNA expression, microRNA expression, DNA methylation, and expression of ∼ 200 proteins/phosphoproteins. The availability of multiple data types has enabled res...
In the framework of entropy-based inference, the power-law distributions of biological networks simply represent the most preferred choice that maintains the fixed internal order of the sub-networks. Entropic scheme for inductive inference In addition to the use of entropy as an information measure,...
at an early stage of evolution, a genome is likely to utilize random segmental duplication, which would maximize reduced Shannon information. These insights not only provide a clue to the origin of evolution but also may shed light on further questions, such as which genes are responsible for ...
In CHOICE (NCT00109161), add-on subcutaneous high-dose daclizumab (2 mg/kg every 2 weeks,n = 75) could significantly reduce the number of new/enlarged gadolinium-enhanced lesions (GELs) (= pSE) in MS patients (92% relapsing–remitting MS (RRMS), 8% SPMS) with active disease desp...
2. Choice of the MM force field (including the MM parameters for the QM region). 3. Partitioning of the system into QM and MM regions with due attention paid to any chemical bonds that straddle the two regions. 4. Type of simulation (e.g., an MD simulation, or calculation of pote...
Your privacy, your choice We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including ...
Your privacy, your choice We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including ...