Multiple myeloma (MM) is a hematological cancer characterized by the abnormal proliferation of plasma cells. Initial treatments often include immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs). Despite salient p
Bispecific T-cell engager antibodies (BiTEs), the new kids on the block, comprise another important class of immunotherapies being explored in RRMM. Blinatumomab, an anti-CD19 BiTE for relapsed/refractory B-cell precursor acute lymphoblastic leukemia, was the first to be approved for clinical use ...
Each of the new modalities designed to mitigate or overcome cancer drug resistance in MM has faced inherent and acquired resistance mechanisms[21]. For example, soluble BCMA renders MM cells resistant to the cytolytic actions of BCMA-directed BiAb/BiTES and CAR-T cells by serving as a competi...
In the meantime, CBS 2's Charlie De Mar reported, the coyote was still on the loose Wednesday night. Police drove squad cars along the running paths in the park of Lincoln Park with their spotlights shining. One officer said over police radio that he planned to reach out to the nearby L...
happen through the transfer15, or spill-over16, of the individuals’ knowledge, skills, or beliefs regarding the first, “gateway”, behavior5. Applied to infectious diseases, such as malaria, behavior carry-over would explain why people who use bed nets to avoid mosquito bites are more ...
one of the oldest neighborhoods in Buenos Aires. Thanks to its amazing architecture and hip atmosphere, this ancient neighborhood is really blooming. Walk its cobbled streets, where the city’s colonial past seems to come back to life, making a stop atPlaza Dorrego, best known f...
"Software Snack Bites" #26 - Marten Mickos (CEO, HackerOne & prev CEO, MySQL & Eucalyptus Software) - The OG of Open Source, Lessons Learned Scaling Multiple Enterprise Software Startups, Tactical Leadership Learnings (Podcast Episode 2023) - Plot summar
Multiple myeloma (MM) remains an incurable hematological malignancy disease characterized by the progressive dysfunction of the patient’s immune system. In this context, immunotherapy for MM has emerged as a prominent area of research in recent years. Various targeted immunotherapy strategies, such as...
bites, skin abnormalities, or joint complaints. Consequently, the patient was intubated and transferred for a magnet resonance imaging (MRI) scan. Cranial MRI showed an area of restricted diffusion in the left insular cortex without hyperintense signal changes on fluid attenuated inversion recovery (...
Mounting evidence underscores the transformative role of various immunotherapies, such as novel monoclonal antibodies, bispecific T-cell engagers (BiTEs), and antibody–drug conjugate (ADC) therapies as innovative treatment modalities for R/R MM [199]. These approaches can potentially complement CAR T-...