We found that most of the alleles under positive selection were associated with protective effects against specific pathogens and/or infectious diseases (disease or pathogen associated/total selected in ancestry path: pan-ancestry, 11/14; ANA, 8/9; CHG, 6/9; EHG, 6/7; WHG, 17/18; ...
Improving the adaptability of temperate maize largely depends upon the use of tropical maize germplasm, which hosts rich sources of favorable genes and alleles67, particularly for tolerance to abiotic and biotic stresses. A shortcut to the favorable alleles hosting in tropical maize is to develop ...
THrs6356,COMTrs4680,MAOBrs1799836,DBHrs1611115) [188].DDCrs921451 minor allele “C” was associated with an increased risk of MSA, especially in male subjects, while haplotype analysis showed the “T-T” haplotype inTHrs6356 andDDCrs921451 risk alleles reduced ...
It is widely believed that complex polygenic inheritance patterns involving HLA-DR and -DQ class II genes contribute to MS susceptibility, and current evidence indicates that disease risk vs disease outcome may be associated with distinctly different HLA class II alleles. We have recently shown that...
The Y-axis shows the scaled average polygenic risk score (PRS) in the population, ranging from 0 to 1, with 1 corresponding to the maximum possible average PRS (i.e. when all individuals in the population are homozygous for all positive risk alleles) and the X-axis shows time in units ...
[122]. It is unclear if the larger number of CAG repeats in normal alleles ofATXN1andATXN2amongst Caucasians is a contributory factor [123]. These expansions seem to be more associated with MSA-C than MSA-P, but more data are still needed as cases have been reported in both groups [...
Starting with a single significant QTL in the F2 population31, more than 20 loci have been shown to contribute to long-term responses in Virginia population, many of which being linked, epistatic and contributing minor effects from alleles present as standing variations in the base-population32. ...
Early family-based studies of SLE revealed high heritability (~66%) and a most probable model of inheritance in which multiple minor polygenic effects were acting in an additive fashion7,8. Genetic linkage studies of multicase families provided the first evidence about the location of susceptibility...
Allen M, Sandberg-Wollheim M, Sjogren K, Herlich HA, Petterson U, Gyllensten U . Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles.Hum Immunol1994;39: 41–48. CASPubMedGoogle Scholar ...
MAS is a useful tool to impose additional selection for useful alleles at any stage of the breeding cycle. However, while the cost of genotyping has severely dropped in recent years. The use of MAS is subject to marker availability, which remains one of the biggest challenges. In particular,...