Alleles usually occur in pairs, one on each HOMOLOGOUS CHROMOSOME in a DIPLOID cell nucleus. When both alleles are the same the individual is described as being a HOMOZYGOTE; when each allele is different the individual is a HETEROZYGOTE. The number of allelic forms of a gene can be many (...
All of the lost alleles of these loci were transmitted from the unaffected father and not from an affected mother. This is the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 and supports the idea that similar allelic deletion of MEN1 locus on chromosome 11 ...
These constitute the haploinsufficient resistance alleles in the EGI design (Fig. 1a, c). To generate viable promoter mutations, flies expressing germline active Cas9 nuclease15 were crossed to homozygous sgRNA-expressing strains16 or were directly microinjected with sgRNA expression constructs. ...
All of the lost alleles of these loci were transmitted from the unaffected father and not from an affected mother. This is the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 and supports the idea that similar allelic deletion of MEN1 locus on chromosome 11 ...
However, SEX was not associated with any alleles from these loci, which suggested that SEX was not on Ssa02 in these families. Mapping of SEX to Ssa06 in Tasmanian Atlantic salmon A screen of these seven Tasmanian Atlantic salmon families using 64 SNP markers, distributed across the genome, ...
展开 关键词: Humans Chromosome Deletion Globins DNA-Directed DNA Polymerase Polymerase Chain Reaction Pedigree Haplotypes Gene Amplification Alleles Polymorphism, Restriction Fragment Length DOI: 10.1093/nar/17.20.8392 被引量: 98 收藏 引用 批量引用 报错 分享 全部...
A single mutant allele or a pair of mutant alleles has been implicated as the cause of some recognizable multiple malformation syndromes of prenatal onset. Testing technology has dramatically altered the ability of the laboratory to assist the clinician when the pattern of malformation is...
The evolution of quantitative characters depends on the frequencies of the alleles involved, yet these frequencies cannot usually be measured. Previous gro... NH Barton,HP De Vladar - 《Genetics》 被引量: 87发表: 2009年 Genetic interactions controlling sex and color establish the potential for sex...
perhaps this would be incompatible with terminal differentiation of PCs and their homing to the BM. Also IgH translocation groups are mutually exclusive, although double translocations have been reported in HMCLs (e.g. KMS11 carries both a MAF and FGFR3 translocation on the two IgH alleles). ...
The individual genomes of sexually reproducing species are typically highly collinear to enable physical exchange of alleles during meiosis. This exchange ensures the generation of diversity and the removal of deleterious alleles1and at the same time protects the offspring from major mutations changing th...