Although individual humans (and all diploid organisms) can only have two alleles for a given gene, multiple alleles may exist at the population level such that many combinations of two alleles are observed. Note that when many alleles exist for the same gene, the convention is to denote the ...
Finally, sequence comparison of the locus within populations and between species revealed a common origin of the allele controlling the blotched morph followed by a pattern of sequential appearance of derived alleles that gave rise to morph diversity. The coupling of the evolutionary history of this...
how genetic susceptibility interacts with environmental risk factors at the population level, multiple sclerosis-associated risk factors and contemporary causation theory.Two large genomic studies have confirmed the unambiguous associations with the DRB1 and DQB alleles of the human leucocyte antigen class II...
linkages and branching structures, but also a remarkable degree of intra- and inter-species diversity [1,2]. The latter has long been one of the more puzzling aspects of their biology. One reasonable
Alleles that confer multiple disease resistance (MDR) are valuable in crop improvement, although the molecular mechanisms underlying their functions remain largely unknown. A quantitative trait locus, qMdr 9.02 , associated with resistance to three important foliar maize diseases-southern leaf blight, gra...
still needs to be analyzed whether local populations show the same level of diversity or if their haplotypes in HOT regions are more similar and still exchange alleles, we have observed the negative consequences of reduced meiotic recombination in this small world-wide population including the ...
Particular cases examined are K allele models, the infinite alleles model, and the stepwise mutation model. The two-locus infinite allele model is examined at the molecular level and a joint probability generating function is found for the number of heterozygous sites at each locus in two ...
Interestingly, alleles or haplotypes from individuals of tetraploid O. punctata did not form a monophyletic clade in all nuclear and chloroplast gene trees, implying recurrent origins of the tetraploid O. punctata. We estimated the time of origin of BBCC tetraploids by utilizing relaxed clock ...
Biology of PPAR gamma in cancer: a critical review on existing lacunae. Peroxisomal proliferator activated receptor (PPAR) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of targ... Anand Krishnan, S. Asha Nair, M. Radhakrishna Pillai - 《Current...
a SBS5 mutation burden on duplicated (CN = 2) and non-duplicated (CN = 1) alleles of large chromosomal gains occurring in the same time window (top), and molecular time estimates based on the corrected ratio of duplicated and non-duplicated mutations (dots below). 95% confidence...