此外,2007年Lou等提出了一种基于MDR基本原理的扩展方法——广义多因子降维法。 广义多因子降维法 (generalized multifactor dimensionalityreduction,GMDR),又称基于计分的多因子降维法 (score-based MDR)。该法可以通过将广义线性模型的概念引人到MDR中,使其不但能够分析连续变量,且能够纳入协变量,从而控制协变量引起...
Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS. Motivation: Epistasis, the presence of gene鈥揼ene interactions, has been hypothesized to be at the root of many common human diseases, but current genome-... Greene,S Casey...
多因子降维法 multifactor dimensionality reduction MDR “因子”是交互作用研究中的变量(如基因型或环境因素) “维”是指研究的多因子组合中因子(如基因型)的数目 “降维”以疾病易感性分类(高危、低危)的方式建模,将研究中的多个因子看作一个多因子组合(基因型组合),这样就把高维的结构降低到一维两水平(即高危...
We have previously developed the multifactor dimensionality reduction (MDR) method to identify gene-gene and gene-environment interactions (Ritchie et al. AJHG 69, 2001). In brief, MDR is a method that reduces the dimensionality of multilocus information to identify polymorphisms associated with an ...
MDR,Multifactor Dimensionality Reduction (多因子降维法) to detect&nb 1.candidate SNPs. 2. 根据SNP combination 得到不同的genotype (diplotype)。 3.1. case-control样本: 计算每种genotype中 case:control 比, 大于threshold (通常选1) 记做high-risk, 小于threshold 记做low-risk. 3.2. family ...
广义多因子降维法 (generalized multifactor dimensionalityreduction,GMDR),又称基于计分的多因子降维法 (score-based MDR)。 该法可以通过将广义线性模型的概念引人到MDR中,使其不但能够分析连续变量,且能够纳入协变量,从而控制协变量引起的干扰,提高预测的准确度,是MDR方法的一种扩展。
多因子降维法(Multifactor Dimensionality Reduction) 疾病遗传易感性(Genetic Predisposition to Disease) 离子通道(Ion Channel…new.med.wanfangdata.com.cn|基于8个网页 例句 释义: 全部,多因子降维法 更多例句筛选 1. The application of multifactor dimensionality reduction for detecting gene-gene interactions 应用...
Among those, the generalized multifactor dimensionality reduction (GMDR) method extends MDR to both dichotomous and continuous phenotypes and allows for the adjustment of covariates such as age, sex, and other clinical variables. In this study, we focus on gene-gene and/or gene-environment ...
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关键词: Genetics Statistics Model Selection with Epistasis| A Focus on Comparative Performance and Prediction to Improve the Usability of Multifactor Dimensionality Reduction NORTH CAROLINA STATE UNIVERSITY Alison Motsinger-Reif Winham Stacey J 年份: 2011 ...