multi-target drugspolypharmacologyschizophreniaIntroduction: Schizophrenia is a complex psychiatric disease (or a conglomeration of disorders) manifesting with positive, negative and cognitive symptoms. The pathophysiology of schizophrenia is not completely known; however, it involves many neurotransmitters and ...
doi:10.1002/9781118098141.ch22Cavalli, AndreaBolognesi, Maria LauraJohn Wiley & Sons, Inc.Cavalli A, Bolognesi ML (2012) Multitargeted Drugs for Treatment of Alzheimer's Disease. Polypharmacology in Drug Discovery: John Wiley & Sons, Inc. pp. 441–458....
Mono-targeted drugs can be of limited efficacy against complex diseases. Recently, multi-target drug design has been approached as a promising tool to fight against these challenging diseases. However, the scope of current computational approaches for multi-target drug design is limited. DeepLig pres...
Therefore, this topic is the use of multi-target drug design principles, the design of drugs that target tumor vasculature and its synthesis, the specific work are as follows: 翻译结果2复制译文编辑译文朗读译文返回顶部 null 翻译结果3复制译文编辑译文朗读译文返回顶部 Therefore, this issue is the us...
Prevention and intervention for skin adverse effects in multi-target molecular targeted drugs treatment DOI:10.3969/J.issn.1672-6790.2017.04.035 中文关键词:抗肿瘤药/副作用皮肤表现分子靶向治疗毒性作用 英文关键词:Antineoplastic agents/adverse effectsSkin manifestationsMolecular targeted therapyToxic actions〖FL...
Therefore, drugs capable of inhibiting ChE might have beneficial therapy effects on the cognitive, functional, and behavioural symptoms of AD. As a result, the development of the inhibitor targeting ChE, especially for AChE, has been an intensive research focus and a large number of AChE ...
days. The effect might correlate with an effective therapeutic module related to anticoagulation and the regulation of cholesterol metabolism. Our study provides a novel strategy to detect the effective therapeutic module of multi-target drugs based on modular flexibility in differentially responsive ...
A notable point is that the antibiotic targets of the herb extract are similar to the targets of commonly used antibiotic drugs, including bacterial cell wall biosynthesis, bacterial protein synthesis, and bacterial DNA replication and repair. In addition, the herbal antibiotic inhibits the etiological...
discovery to thefinal medication, is an expensive, lengthy and incremental process [3]. Finding new uses for old or failed drugs is much faster and more economical than inventing a new drug from scratch, as existing drugs have known pharmacokinetics and safety profiles and have often ...
Drugs 79, 23–29 (2019). Article CAS PubMed PubMed Central Google Scholar Dillon, E. L. et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J. Clin. Endocrinol. Metab. 94, 1630–1637 (...