Introduction:Current findings on multifactorial diseases with a complex pathomechanism confirm that multi-target drugs are more efficient ways in treating them as opposed to single-target drugs. However, to design multi-target ligands, a number of factors and challenges must be taken into account. ...
multi-target drugspolypharmacologyschizophreniaIntroduction: Schizophrenia is a complex psychiatric disease (or a conglomeration of disorders) manifesting with positive, negative and cognitive symptoms. The pathophysiology of schizophrenia is not completely known; however, it involves many neurotransmitters and ...
Notwithstanding the success of combination therapy, the use of a single drug that modulates several targets might be therapeutically advantageous over the use of drugs in combination. In cancer, the design and synthesis of new molecules that simultaneously modulate multiple biochemically distinct oncogenic...
doi:10.1002/9781118098141.ch22Cavalli, AndreaBolognesi, Maria LauraJohn Wiley & Sons, Inc.Cavalli A, Bolognesi ML (2012) Multitargeted Drugs for Treatment of Alzheimer's Disease. Polypharmacology in Drug Discovery: John Wiley & Sons, Inc. pp. 441–458....
de Lera and Ganesan Clinical Epigenetics (2016) 8:105 DOI 10.1186/s13148-016-0271-9 REVIEW Epigenetic polypharmacology: from combination therapy to multitargeted drugs Angel R. de Lera1* and A. Ganesan2* Open Access Abstract The modern drug discovery process has largely focused its attention in...
dependent activity of chemotherapy, especially in the EGFR wild-type population. Considering that in western countries, this part represents most of all the patients who receive any treatment for A-NSCLC, we can understand how the combination of these two different kind of drugs is not useful.[...
These drugs were combined to generate the compound library that will be utilised for virtual screening. These drugs or ligand molecules were prepared using the LigPrep tool of Schrodinger suit32,33. Ligand preparation using the Ligprep tool reduces the Lewis structure formation of the ligand ...
6. Acetylcholinesterase inhibitor drugs Currently, the most commonly drugs used to treat Alzheimer's disease are acetylcholinesterase/cholinesterase inhibitors (ChE-Is). The first ChE-I to be approved for the symptomatic therapy of AD was tacrine, but it is no longer used due to hepatotoxicity. Cu...
Therefore, drugs capable of inhibiting ChE might have beneficial therapy effects on the cognitive, functional, and behavioural symptoms of AD. As a result, the development of the inhibitor targeting ChE, especially for AChE, has been an intensive research focus and a large number of AChE ...
Prevention and intervention for skin adverse effects in multi-target molecular targeted drugs treatment DOI:10.3969/J.issn.1672-6790.2017.04.035 中文关键词:抗肿瘤药/副作用皮肤表现分子靶向治疗毒性作用 英文关键词:Antineoplastic agents/adverse effectsSkin manifestationsMolecular targeted therapyToxic actions〖FL...