In the final step, for the hematological and biochemical markers related to both breast cancer incidence and mortality risk, the multi-state survival models were used to assess the effects of the biomarkers on transitions from event-free (State 1) to in-situ breast cancer (State 2), invasive...
However, the phenotype model does not include cognitive impairment, a highly prevalent condition associated with functional decline and disability [2]. The frailty index based on the cumulative deficit model is defined as the proportion of accumulated deficits (symptoms, signs, functional impairments, ...
An alternative two-step model is also considered for cases in which the competing risks model is not warranted. The chapter then moves to a discussion of models for repeated events, detailing several approaches to handling the dependence of survival times across cases. The chapter concludes with ...
In high-purity TCGA melanoma samples, BRAF mutations were not associated with MCS (Supplementary Fig. 5); thus, we cannot exclude a potential selective advantage for BRAF mutated MEL samples when grown in vitro. At the nucleotide level, mutations were dominated by C>T transitions, as is ...
The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lipidomics, HTT g
Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell-cycle progression and survival in cancer cells. Cancer Res. 2017, 77, 1575–1585. [Google Scholar] [CrossRef] Li, X.; Li, H.; Qin, L.; Xu, X. Bayesian network inference on departure time choice behavior....
Understanding the ecology of hosts and aspects of their physiology that may influence the parasite infection is essential to better understanding of hemoparasite infections and how parasites influence their native hosts, through decreasing reproductive success, lifespan, and/ or survival....
(B) Estimation of the half-life of klotho mice (n = 5) by survival-curve analysis. (C) Histological observations of (i) liver tissue from 7-week-old KL + and KL − showed that it did not exhibit any signs of aging relative to WT mice, as was also true for (ii) heart tissue...
Fig. 3: Survival, 10-year, and lifetime risk curves. a We demonstrate the singular projected disease-free curve by MSGene for a non-smoking individual not on anti-hypertensives at age 40 of low, medium or high genomic risk from the healthy to CAD transition. b We demonstrate the MSGene...
Stomach neoplasms are the fifth common cancer worldwide. The related factors for survival following stomach neoplasms are well-studied; however, information on recurrent events is limited. This study aimed to identify the related factors on recurrent and deaths following stomach neoplasms. ...