Numerous potential drug targets, including G-protein-coupled receptors and ion channel proteins, reside on the cell surface as multi-pass membrane proteins. Unfortunately, despite advances in engineering technologies, engineering biologics against multi-pass membrane proteins ...
Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides Recent advances in the clinical development of oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs, have att... Kohshi Kusumoto,Kiyomi Sasaki,Yasunori Uchida,....
Structure of the model multi-pass membrane protein VSD4-NavAb chimera. The VSD4-NavAb chimera (PDB accession code 5EK0) is a homotetrameric protein with a central pore domain and four voltage sensing domains. Shown here is the side view of the tetramer, with one of the subunits shown ...
Association propensities of the viral oncoprotein, latent membrane protein-1 (LMP-1), and the E. coli membrane-integral diacylglycerol kinase (DAGK) were studied by Multi-Tox, highlighting residues of particular mechanistic importance. Both homo- and hetero-oligomerizations were studied....
Predicting membrane protein type by functional domain composition and pseudo-amino acid composition Given the sequence of a protein, how can we predict whether it is a membrane protein or non-membrane protein? If it is, what membrane protein type it belon... YD Cai,KC Chou - 《Journal of ...
These interactions are generally of very low affinity and often require specific motifs generated via post-translational processing; furthermore, amphipathic membrane-spanning proteins are difficult to manipulate biochemically. The Duffy Antigen Receptor for Chemokines (DARC), a multi-pass G-protein ...
Although flaviviruses co-opt the function of the host endoplasmic reticulum (ER) membrane protein complex (EMC) during infection, a mechanistic explanation for this observation remains unclear. Here, we show that the EMC promotes biogenesis of dengue virus (DENV) and Zika virus (ZIKV) non-...
2011. Multi-Tox: application of the ToxR- transcriptional reporter assay to the study of multi-pass protein trans- membrane domain oligomerization. Biochim. Biophys. Acta 1808: 2948 -2953. http://dx.doi.org/10.1016/j.bbamem.2011.07.008....