TranscriptomicsHypoxic-ischemic brain injury is a common cause of mortality after cardiac arrest (CA) and cardiopulmonary resuscitation; however, the specific underlying mechanisms are unclear. This study aimed to explore postresuscitation changes based on multi-omics profiling.#A CA swine model was ...
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utilized 9,491 clinical cases and proton density f...
integrative omics, "panomics" or "pan-omics" is a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome, metabolome, and microbiome; in other words, the use of multiple omics technologies to study life in a concerted ...
We sought to identify PTM sites on the circadian clock proteins. In total, 57 sites on circadian clock proteins that can be modified by phosphorylation or ubiquitylation were identified in this multi-omics study (Supplementary Table1), including the recently reported mouse PER2 Ser693/Ser697 and...
We first discuss incorporating multi-omics approaches into theory-rich, intensive longitudinal study designs to characterize, in high-resolution, the transition to stress-related multisystem dysfunction and disease throughout development. Next, we discuss how multi-omics approaches should be incorporated ...
In our research, we carried out an extensive multi-omics study, gathering tissue samples from IVL cases, uterine fibroid, and normal myometrium. The single-cell RNA sequencing analysis revealed a notable difference in cell composition between IVL and uterine fibroid. Additionally, H&E staining ...
In this study, we evaluated the extent of the genetic variation among 543 wheat accessions differing in K-deficiency tolerance at the seedling and adult plant stages. Two accessions, KN9204 and BN207, were identified as extremely tolerant and sensitive to K-deficiency, respectively. The accessions...
These findings are summarized here, and our view on how to study NK cells using "multi-omics" is highlighted. We also describe "-omics" analyses of the relationships between NK cells and viral infection, tumorigenesis, and autoimmune diseases. Ultimately, a deeper and more comprehensive ...
Chinese Journal of Integrative Medicine, 2021年12月20日 12月20日,中国中医科学院西苑医院刘建勋研究员带领的团队,在期刊 Chinese Journal of Integrative Medicine 发表题为 Application and Prospect of Platelet Multi-Omics Technology in Study of Blood Stasis Syndrome 的论文。
study is the use of metagenomics to generate testable hypotheses on the mechanisms of disease evasion by the host33. In a study to analyze the effects of directly fed microbes on the rumen microbiome of cattle, Fomenky et al.34applied 16S RNA gene sequencing of the V3 to V5 region of ...