Wright’s metaphor of the fitness landscape has shaped and conditioned our view of the adaptation of populations for almost a century. Since its inception, and including criticism raised by Wright himself, the concept has been surrounded by controversy. Among others, the debate stems from the intr...
Multi-heme cytochromes provide a pathway for survival in energy-limited environments. Sci. Adv. 4, eaao5682 (2018). ADS PubMed PubMed Central Google Scholar Carlson, H. K. et al. Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction ...
covering several covariables from the host and microbial domains are integrated to reveal the nature of interactions87. As a result, additional omics data are needed for a full description of microbial activities, such as the abundances of RNA (metatranscriptome), proteins (metaproteome), and metab...
while the Markov Chain Monte Carlo (MCMC) procedure also suffered a substantial computational burden [15]. In several simulation and actual studies, nonparametric ML methods behaved better, primarily due to their superior prediction ability [16,17]. Therefore...
This intends to accelerate progress toward SDG 3.2, focused on neonatal survival. The NEST360 Alliance set out to co-design and operationalise a core neonatal inpatient dataset tool to measure individual-level quality of care to inform quality improvement, measure impact and enable prompt action in...
which counteracts the effects of local adaptation, reducing the mean fitness of populations (i.e., migration load)2. Fundamentally, gene flow is ensured when dispersal is followed by reproduction and subsequent offspring survival6. A common confusion prevails between demographic connectivity (i.e., ...
Since extracellular signal-regulated kinases (ERK1/2) play a major role in neuronal survival and differentiation [38], we also examined the effects of herbal extracts on ERK 1/2 phosphorylation. YXT and RP treatments significantly enhanced the phosphorylation of ERK (Fig. 6B). Similar to CREB,...
Besides,Pvalue for the log-rank test of survival analysis is used to evaluate the significance of the difference between cancer subtypes. Statistical significance threshold is set to 0.05. If thePvalue is less than 0.05, it indicates a significant difference between the population survival curves ...
The evolution of gene expression and regulation is a major source of phenotypic diversity46,47,48. To explore the roles of hypoxia-adaptive genes in long-term adaptation and short-term acclimatization, we integrated gene expression data with genome sequencing data to perform a joint analysis. We ...
Not publicly disseminated or unavailable to public upon request from source Not specific to Afghanistan Target population is Afghan refugees no longer in the country or children older than 5 years Not written in English Global or multi-country study without specific data from Afghanistan, rather only...