1h). The tumor suppressors TP53 (p53) and CDKN1A (p21CIP1)17 were significantly upregulated in C6 and C7. Furthermore, the senescence-associated secretory phenotypes18 (SASP) factor IL6 and β-galactosidase (GLB1) were expressed at higher levels in C5, as were the genes encoding heat ...
Tumor suppressors fall into six main categories: (a) cell cycle control genes or cell division inhibitors, (b) hormone or growth factor receptors, (c) checkpoint control genes, (d) apoptosis inducers, (e) cell adhesion genes, and (f) DNA repair genes. In contrast to tumor suppressor genes...
As for CXCR4 mutations, the transcriptomic profile, relative to that of solely MYD88-mutated individuals, shows diminished B-cell differentiation, downregula- tion of tumor suppressors overexpressed by MYD88 mutation, and alternative activation of the toll-like receptor 7 (TLR7) pathway [95]. As...