A role for the commensal microbiota has been implicated in colon MP differentiation and/or maintenance in several studies, with lower numbers of both monocyte-derived and tissue-resident long-lived MPs present in germ-free (GF) mice,5,6,12,25,26however, a substantial number of mature colon M...
26 Thus, innate immune cells colonize the lung very early during fetal development and can react to intrauterine inflammation. In addition to DCs and macrophages, natural killer (NK) cells represent a large proportion of the innate immune cells found in the fetal lung.27 A proportion of these ...
The early stage of the tumor carcinogenesis process is related to immune response changes in cytokine levels, immune cell density, and immune cell function.121 How do pathogens interact with the immune response beyond inducing inflammation? Tregs play a key immune regulatory role during infection and...
Prostaglandin E2-induced inflammation: relevance of 24. Halter, F., Tarnawski, A. S., Schmassmann, A. & Peskar, B. M. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut. 49, 443–453 (2001). 25. Stenson,...
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD 2019, Nature Reviews Gastroenterology and Hepatology Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis 2008, Journal of Clinical Investigation S100 proteins ...
Abstract: Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial ...
Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn's disease. J. Clin. Gastroenterol. 2014, 48, 513–523. [CrossRef] [PubMed] 37. Sam, Q.H.; Chang, M.W.; Chai, L.Y. The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host. Int. J....