The present review will focus on the recent developments in identifying the TRPML1 function.Grace A CollettiKirill KiselyovBach G: Mucolipin 1: endocytosis and cation channel-a review. Pflugers Arch 2005, 451:313-317.
Rabbit Anti-mucolipin 1 Cat. Number: Anti-mucolipin 1抗体KL-18731R Quantity size: 0.2ml Concentration: 1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Background: This gene encodes a memberof the transient receptor potential (TRP) cation channel gene fam...
ML-SA1 抗 DENV2 RNA 和 ZIKV RNA 的 IC50 值分别为 8.3 μM 和 52.99 μM。ML-SA1 诱发自噬。ML-SA1可用于广谱抗病毒研究。 Application ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist. AI解读 关联靶点(人) 关联靶点(其它种属) 作用...
ML1 is suggested to be a multiple subconductance and nonspecific cation channel, where activity is modulated by both Ca2+ and pH (12, 13), indicating that this protein may be involved in trafficking or fusion events between late endosomes and lysosomes in the late endocytic pathway (14, 15)...
Current recording, however, showed that TPC1 and TPC2 did not affect the activity of wild-type TRPML1 or constitutively active TRPML1(V432P). N-terminally truncated TPC2 (TPC2delN), which is targeted to the plasma membrane, also failed to affect TRPML1 and TRPML1(V432P) channel function...
we discovered the endolysosomal cation channel mucolipin 3 (TRPML3) as a regulator of MMP-12 reuptake from broncho-alveolar fluid, driving in two independently generatedTrpml3−/−mouse models enlarged lung injury, which is further exacerbated after elastase or tobacco smoke treatment. Mechanistica...
For these general pathways, it has been postulated that Ca2+ is released through unidentified Ca2+ channels from the lumen of vesicles and organelles1–3. Transient receptor potential (TRP) proteins are members of a superfamily of Ca2+-permeable cation channels that are localized at the plasma ...
MLN1 is a non-specific cation channel, and its putative structure attributes it to the TRP superfamily; thus, the gene is also referred as TRPML1. Over 16 MLIV-causing mutations, including two founder mutations in the Ashkenazi population, have been identified hitherto. Atypical increased ...
MLIV is caused by mutations in the MCOLN1 gene, encoding the transient receptor potential (TRP) cation channel family member mucolipin-1 (TRP-ML1). While previous work has provided insight into the role of this protein in progression of MLIV, a detailed knowledge of TRP-ML1 function and ...
Mucolipin-3 (TRPML3) is an inwardly-rectifying cation channel that primarily localizes to intracellular vesicles, particularly late endosomes and lysosomes, and whose cellular function remains unknown. The gene was first discovered as the genetic cause of deafness in the Varitint-waddler (Va) ...