06 May 2024 Corvus Pharmaceuticals initiates phase-I clinical trials in Non-small cell lung cancer (Monotherapy, Combination therapy, Late-stage disease) in China (IV) 05 Jan 2024 Corvus Pharmaceuticals completes a phase I trial in Cancer (Late-stage disease, Monotherapy, Second-line therapy or...
OFF-label use (Drugs)CLINICAL trialsAnastrozole is a highly selective nonsteroidal aromatase inhibitor. It is approved for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Nonetheless, aromatase inhibitors have also been used off-label for many years in men. This ...
In a study of individuals prescribed 3 months of opioids for chronic noncancer pain, patients that had the single nucleotide polymorphism (SNP; rs1799971- A118G) for the minor allele 118-GG had decreased sleep adequacy scores and increased self-reported sleep problems in the SLP-9 index ...
The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as MEK...
Clinicopathological significance of altered loci of replication error and microsatellite instability-associated mutations in gastric cancer. Replication errors (RERs) judged by microsatellite instability and its associated mutations have been recognized as an important mechanism in tumorigenesis... MS Wu,CW ...
Interventions for preventing oral mucositis in patients with cancer receiving treatment: Oral cryotherapy Oral mucositis is a side effect of chemotherapy, head and neck radiotherapy, and targeted therapy, affecting over 75% of high risk patients. Ulceration can... P Riley,Anne㎝arie Glenny,HV Wort...
A phase I clinical trial to study the safety of treatment with tipifarnib combined with bortezomib in patients with advanced stages of myelodysplastic syndrome and oligoblastic acute myeloid leukemia P. Muus,S. Langemeijer, …,T. de Witte ...
treatment of various types of cancer, including colon, gastric and metastatic liver cancer (9). Clinical trials of oxaliplatin in advanced HCC revealed moderate activity, but limited efficacy (10). The reason for this is partly intrinsic multidrug resistance and acquired drug resistance following ...
that the active ingredients of QC can target key proteins associated with multiple biological processes and signaling pathways related to DR, but the functional changes in these factors and the profound influences of treatment need to be elucidated in further animal experiments and clinical trials. ...
Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats Preclinical studies may elucidate the meaning of biomarkers applicable to epidemiologic studies and to clinical trials for cancer prevention. No study has ... D Francesco,RM Balansky,I Alberto...