Epstein–Barr virus (EBVMethotrexate (MTX) has been used as standard therapy for patients with rheumatoid arthritis (RA). MTX-related lymphoproliferative disorder (MTX-LPD) is a heterogeneous group of lymphoid proliferations or lymphomas that can develop in patients treated using MTX. We report a ...
60%病人在停用MTX后少部分缓解,大部分对停用MTX有反应的病例为EBV阳性。在停用MTX后,约40% DLBCL病例、30%HL病例、100%HL样LPD病例和100%淋巴浆细胞淋巴瘤能缓解。DLBCL总生存率约为50%。HL和淋巴浆细胞淋巴瘤总的生存率均为75%。查看全文 甲氨蝶呤相关的淋巴增殖性疾病的病理病因分析 近2/3病人在停用MTX后...
However, enough evidence about the relation with EBV infection and spontaneous regression of MTX-LPD is not presented. In addition, biomarker predicting a spontaneous regression of MTX-LPD has not been clarified.ObjectivesWe examined the clinical characteristics of MTX-LPD in Japanese RA patients and...
EBVlymphocyteMTX-LPDRAObjectives: To determine the clinical characteristics of methotrexate-associated lymphoproliferative disorder (MTX-LPD). Methods: In this study, 12 RA patients who developed MTX-LPD were assessed. The peripheral blood lymphocyte (PBL) count at the onset of MTX-LPD was compared ...
EBV was detected in 10 of 31 cases. MTX was stopped soon after the diagnosis of MTX-LPD in all but one patient who was very active RA and showed no aggravation of LPD. After MTX cessation, 16 patients needed chemotherapy for LPD. LPD resolved spontaneously in the other 22 patients, but...
It is of particular interest that the annual incidence of MTX-LPD increases 1.58 times with only 1mg increment of MTX a week. It is also notable that all of the lesions regressed spontaneously so far after cessation of MTX, and the connection with EBV infection was found in all investigated...