mTORC1PTHrPWnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association ...
这些数据显示PCP/JNK 和mTORC1调控了wnt16抑制软骨细胞肥大的进程。 PTHrP信号通路是在骨骼发育中调控软骨细胞肥大的最主要的一个通路之一。我们发现 PTHrP信号的强度在wnt16-shRNA转染的情况下被明显的抑制,而在添加wnt16的情况下被明显...
mTORC1 activity is required for PTHrP transcription PTHrP is a main regulator of endochondral bone development under the control of the hedgehog pathway by its downstream effectors in the Gli family. IHH stimulates transcriptional activity of Gli transcription factors toward PTHrP to promote chondrocyte ...
mTORC1通路如何调控PTHrP来控制软骨细胞增殖分化.三,材料方法1,体内软骨细胞增殖分化时mTORC1通路活性的变化情况.利用免疫荧光观察mTORC1通路活性指标蛋白磷酸化核糖体S6蛋白(pS6)在小鼠E14.5天肱骨,以及P7,P18天胫骨中的表达情况.利用Western blots来分析培养的原代软骨细胞在诱导分化的过程中pS6蛋白的变化情况.利用免疫...
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151. downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002;16:1472-87.mTORC1regulates PTHrP to coordinate chondrocyte growth,proliferation and differentiation. Yan B,Zhang Z,Jin D,...
Conclusions Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential therapeutic target for OA treatment.doi:10.1136/annrheumdis-2018-214200Tong, Wenxue...
mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. Osteoarthritis Cartilage 25, 952-963 (2017).H. Zhang, H. Wang, C. Zeng et al., "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate ...