It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate....
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MTHFR variants that lead to decreased production of neurotransmitters may play a role in OUD. However, lacunae exist for characterizing the prevalence of the MTHFR mutations in an OUD population. The objective of this study was to determine prevalence of the MTHFR gene mutations in a rural Tenness...
de Koning, E. J.et al.Effects of Two-Year Vitamin B 12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations : Additional Results from the B-PROOF Study, an RCT. (2016). doi:10.3390/nu8110748 Coppen, A. & Ba...
That’s not to say that adults don’t have some serious issues with not only MTHFR mutations, but many of the other gene in the methylation pathway can compound how to balance everything. For example, depending on your other genes besides MTHFR, you might be better with tydroxycobalamin ...
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine, encoded by the CCL2 gene [9], that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. MCP-1 is also important in the recruitment of macrophages and leukocytes into the glomeruli and interstitial spaces of ...
MI has a high prevalence especially in the elderly [1]. However, the age of MI onset has decreased because of environmental risk factors and genetic polymorphisms [2]. Myocardial infarction reflects cell death caused by myocardial ischemia. Myocardial infarction may occur with typical symptoms, or...
Ser- um folate, vitamin B-12, and homocysteine and their association with depressive symptoms among U. S. adults [ J]. Psychosom Med, 2010,72(9): 862 -73. [12] Almeida O P, McCaul K, Hankey G J, et al. Homocysteine and depression in later life[J]. Arch Gen Psychiaty, 2008,...
Depressive symptomsHomocysteineMTHFRBackground: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate metabolism in the process of one-carbon cycle and its deficiency results in elevated homocysteine concentration. In this study, we hypothesized that MTHFR C677T polymorphism and ...
BACKGROUND: A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults. OBJECTIVE: We investigated the associations between MTHFR C...