关键字: 亚甲基四氢叶酸还原酶;基因多态性;大剂量甲氨蝶呤;血液恶性肿瘤;安全性;Meta分析 KEYWORDS: Methylenetetrahydrofolate reductase ;Gene polymorphisms ;High-dose methotrexate ;Hematological neoplasms ; 总下载数: 81次 本日下载数: 2次 本月下载数: 81次 文件大小: 619.60Kb*...
MTHFR gene C677T poly- morphism and type 2 diabetic nephropathy in Asian pop- ulations: a meta-analysis. Int J Clin Exp Med. 2015;8 (3):3662-3670.Chen H, Wei F, Wang L, Wang Z, et al. (2015). MTHFR gene C677T polymorphism and type 2 diabetic nephropathy ...
CONCLUSIONS: MTHFR gene is mainly mutant type in C677T site and wild type in A1298C site among Han population in Shaanxi area. Gene polymorphism of above two sites may be associated with the occurrence of coronary heart disease; C677T site mutation may be a risk factor for coronary heart...
MTHFR Acronyms A gene on chromosome 1p36.3 that encodes an enzyme which converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Molecular pathology Defects in MTHFR cause methylenetetrahydrofolate reductase deficiency and increase su...
Methylation & MTHFR Gene Mutation What if something about your genes is making you sick? What if its making you react differently to foods or medicine? Perhaps you have gotten used to feeling poorly because you know it is just how you’vealwaysfelt, yet you know that your discomfort is not...
女十R插:耍N5.亚甲基四氢叶酸还原酶(MTHFR)基因多态性和高同型半胱氨酸血症及脑卒中的关系中文摘要脑卒中是危害人群健康的常见病和多发病。由于目前缺乏有效的治疗方法,针对其危险因素进行预防就显得日益重要。对脑卒中危险因素的研究在国内外已越来越受到重视。同型半胱氨酸血症(HCY)是已获公认的脑血管病独立危险...
type of TT and hyperhomocysteinemia as well as the incidence of cardiovascular disease.Conclusions Higher serum Hcy may be an important toxic substance in end stage renaldisease patients and renal graft recipients.Hyperhomocysteinemia may be related to TT mutation of MTHFR gene in our research ...
Of interest, genetic aberrations affecting B-cell activation such as variants of the B-cell activating factor (BAFF) gene10, a recently described His159Tyr mutation of its receptor (BAFF-R)11, and a mutation of the tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene12 -an NF-κB...
A MTHFR gene variation can lead to nutrient deficiencies, an inability to clear out toxins, estrogen dominance, brain fog, multiple chemical sensitivities, depression, irritability, and anxiety - common Hashimoto’s symptoms.
【Key words】 Anhui province Pregnant woman population MTHFR Gene polymorphism 亚甲基四氢叶酸还原酶(MTHFR)是一种 催化5,10-亚甲基四氢叶酸向5-甲基四氢叶酸不 可逆转换的关键酶,与体内叶酸/同型半胱氨酸 (HCY)的代谢,蛋氨酸的合成以及DNA和RNA 合成有关[1].因此,MTHFR基因的缺陷导致机体 多个基础生化过程...