Meta-analyses of a total 11 studies showed no association between MTHFR 677C>T polymorphism and cervical cancer using all five genetic models (All P values > 0.05). However, subgroup analyses showed the odds of the homozygous TT genotype were much less in cervical cancer cases than in ...
The common MTHFR C677T polymorphism produces an enzyme with reduced activity [5] owing to lowered affinity for its riboflavin cofactor, (flavin adenine dinucleotide, FAD) [6]. The homozygous MTHFR 677TT genotype affects 2–32% of populations worldwide [7] and meta-analyses have estimated that...
Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions. (Translated from eng) Thromb Res. 111, 39-44 (in eng) (2003).Choi BO,Kim NK,Kim SH. Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple ...
名义上 200X 深度的全外显子测序结果，MTHFR 677,C/T 杂合 这个 200X 的全外显子测序也不能保证...
The CT and TT genotypes of the C677T gene polymorphism exhibited substantial risks for having stroke disease [(OR 3.856; P ≤ 0.001); (OR 4.026; P ≤ 0.001), respectively]. The T allele was significantly more prevalent among patients compared to controls. (OR 2.517; (P = ...
However, neither the homocysteine concentration post-FA treatment nor the homocysteine-lowering response of FA supplementation was affected by MTR A2756G polymorphism (Table 3). There was no significant interactive effect between MTHFR C677T and MTR A2756G polymorphisms on the homocysteine-lowering ...
The MTHFR 677C>T polymorphism leads to a modest increase in tHcy. Individuals with the homozygous TT genotype have approximately 0.34 mg/dL higher tHcy levels than those with the wild-type CC variant.44,45 The difference depends mainly on folate status.46 Lack of power may therefore be the ...
结论 MTHFR C677T的3种基因型频率在宁夏汉族冠心病患者和正常人群中的分布无统计学意义.MTHFR基因C677T多态性与冠心病的危险因素Hcy水平、叶酸水平相关.%Objective To investigate the correlation between methylenterahydrofolate reductase (MTHFR) gene C677T polymorphism, homocysteine (Hcy), folate and coronary ...
Background: A high plasma concentration of total homocysteine has been linked to a higher risk of cardiovascular disease. Subjects homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C→ →T mutation have depressed folate and ele- vated homocysteine concentrations. They may have increased...
If both have mutations, your risk of having a homozygous mutation is higher. However, in cases where a person holds two copies of the C677T mutation or one copy of each mutation, they may be at risk of high homocysteine (an amino acid) levels, which may affect the body’s function. ...