3.The amount of a drug present in the body after repeated doses. curative dose Abbreviation:CD The dose required to heal an illness or disease. depth dose The actual amount of radiation exposure at a specific point below the surface of the body. ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook MTD Dictionary Thesaurus Medical Encyclopedia Wikipedia Category filter: AcronymDefinition MTDMounted MTDMaximum Tolerated Dose MTDMotion to Dismiss(legal) MTDMethadone(drug screening) ...
注2:“Overdosing”(过度剂量)指超过MTD的剂量 。DLT = dose-limiting toxicity(剂量限制性毒性);SD = starting dose(起始剂量);RD = recommended dose(推荐剂量);DL = dose level(剂量水平);AUC = area under the curve for drug concentration as a function of time(药物浓度-时间曲线下面积);p(DLT at ...
7.通过结构修饰改变有效载荷效力可能会改变药物的治疗窗口,但不一定会扩大治疗窗口。探索具有更好的“drug-like”特性,如溶解性、渗透性、代谢稳定性和转运体底物不相容的有效载荷可能可以改善ADC的临床效能。 8.基于肿瘤类型、定位和相对于正常组织的抗原表达,抗体应与有效载荷相匹配,以允许足够水平的ADC剂量来克服非...
Select the maximum tolerated dose (MTD) or MTD contour for drug combination trialsSuyu LiuYing Yuan
[4] Nonstandard abbreviations: TB, tuberculosis; AFB, acid-fast bacilli; NAA, nucleic acid amplification; FDA, Food and Drug Administration;E-MTD, Enhanced Mycobacterium tuberculosis Direct Test; Amplicor, Amplicor Mycobacterium tuberculosis Test; RIF, rifampin; INH, isoniazid; and LiPA, Line Probe...
限于本人表述能力和理解能力有限,如有不对,烦请批评指正。更多详细信息,还请大家阅读相关参考文献。 参考文献 Lin R. and Yin G. (2017) Bayesian Optimal Interval Design for Dose Finding in Drug-combination Trials , Statistical...
参考文献: 1.The therapeutic window of antibody drug conjugates: A dogma in need of revision. Cancer Cell.2022 Oct 10;S1535-6108(22)00445-7
Multi-drug 10 in 1 test Panel DOA Urine Cup 肿瘤标记 Tumor Marker Tests (AFP)Alpha-FetoproteinRapid Test (PSA) Prostate SpecificAntigen Qualititive test (CEA) CarcinoembryonicAntigen Test (FOB) One Step FecalOccult Blood Test 美沙酮检测试剂盒,(MTD)Methadone Test...