inhibitor)的p21WAF1/Cip1来在G1/S中抑制细胞周期。 4 4 CN117794584A说明书2/20页 发明内容 [0008]技术问题 [0009]本发明的目的在于,提供一种用于预防或治疗癌症的药物组合物,包含MSH2的基 因或蛋白质的抑制剂或者MSH6的基因或蛋白质的抑制剂作为有效成分。 [0010]并且,本发明的再一目的在于,提供一种治疗...
Can be restored by Proteasome Inhibitor Bortezomib[39] MSH6c.3656C > T; p. T1219I c.1453C > T; p. Q485X c.3907G > A; p. A1303Tglioblastomatemozolomide resistance[110] MSH6p. V397E (p. V397E in human) p. L448P (p. L449P in human) ...
In the final chromatographic step, wild type hMutSα and hMSH2G674A-hMSH6wt were eluted in buffer A (25 mm HEPES, pH 7.5, 0.1 mm EDTA, 10% glycerol, 1 mm DTT, 1× Complete proteinase inhibitor mixture (Roche Applied Science); 0.1% PMSF) containing 100 mm KCl, whereas MSH2wt-MSH6...
Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes. Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes. J Biol Chem. 2000; 275 :36498–36501... AB Clark,F Valle,K Drotschmann,... - 《Journal ...
Flores-Rozas H, Clark D, Kolodner RD (2000) Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nat Genet 26:375 Article CAS Google Scholar Genschel J, Kadyrova LY, Iyer RR, Dahal BK, Kadyrov FA, Modrich P (2017) Interaction of...
In brief, DNA mismatches are recognized by the MutSα complex, an MSH2/MSH6 heterodimer. This interaction enables MutSα to recruit the MutLα complex, itself a heterodimer consisting of the MLH1 and PMS2 proteins. MutLα binding stabilizes the MutSα:DNA interaction and acts as an interface ...