SHIP1 Regulates MSC Numbers and Their Osteolineage Commitment by Limiting Induction of the PI3K/Akt/β-Catenin/Id2 AxisingentaconnectStem Cells & Development
Note that the MSC- like cells derived from both the H9-hECs and YK26-iPSCs shared a very similar surface antigen profile. Osteogenic differentiation Evidence of the multi-potentiality of the derived cells was assessed through tri-lineage differentiation experiments including ...
of this study was to boost the therapeutic effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) by overexpressing the gene TSG-6 through CRISPR activation, and assess the biological activity of EVs from these modified MSCs in vitro on human intervertebral disc (IVD) cells....
MSCs differentiation can be driven by material/cell interface topography, suggesting a unique strategy to manipulate stem cells’ osteoblastic lineage commitment [7], [8], [9]. But micropitted/nanotubular hierarchical topographical effects on MSCs remain to be thoroughly explored. Regarding the ...
Mesenchymal stem cells (MSCs) are crucial for skeletal development, homeostasis, and repair, primarily through their differentiation into osteoblasts and other skeletal lineage cells. Key signaling pathways, including Wnt, TGF-β/BMP, PTH, Hedgehog, and IGF, act as critical regulators of MSC osteogen...