the proliferation and differentiation of OPC are prerequisites for successful remyelination. In progressive disease stages, MS lesions display a relative preservation of OPC, but lack mature oligodendrocytes suggesting that a differentiation block contributes to remyelination failure...
10.Meca-Lallana JE, Casanova B, Rodríguez-Antigüedad A, et al. Consensus on early detection of disease progression in patients with multiple sclerosis. Front Neurol. 2022;13:931014. 11.DeLuca J, Schippling S, Montalban X, et al. Effect...
参考文献: 1.Oset M, Stasiolek M, Matysiak M. Cognitive Dysfunction in the Early Stages of Multiple Sclerosis-How Much and How Important? Curr Neurol Neurosci Rep. 2020 May 22;20(7):22. 2.李二杰, 李磊. 多发性硬化病人认知障碍的研究进展. 中西医结合心脑血管病杂志. 2020;18(02):260-264...
New Drug Molecule May Prevent MS Disease ProgressionABSTRACTDa Hee HanPharmD
13.Oset M, Stasiolek M, Matysiak M. Cognitive Dysfunction in the Early Stages of Multiple Sclerosis-How Much and How Important?. Curr Neurol Neurosci Rep. 2020;20(7):22. 14.Foley FW, Benedict RH, Gromisch ES, Deluca J. The Need for Screening, Assessment, and Treatment for Cognitive ...
As a result of spasticity and balance problems, as well as fatigue, muscle weakness, and other symptoms, many people with MS experience difficulty walking, especially in latter stages of the disease.Tremors (uncontrolled shaking) can occur in some people with MS. Additionally, muscle weakness and...
“The process is going to look different for each patient, and we have to recognize each individual’s needs and the ways they process the stages of their disease,” Sullivan said.Cossoy says most MS clinics screen patients for mental health issues at every visit....
26.Preziosa P, Pagani E, Meani A, et al. Slowly Expanding Lesions Predict 9-Year Multiple Sclerosis Disease Progression. Neurol Neuroimmunol Neuroinflamm, 2022, 9(2). 27.Kappos L, De Stefano N, Freedman M S, et al. Inclu...
A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes ( IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 ...
Nurse With MS Wins Grant to Find Severity, Progression Biomarkers A nurse and PhD candidate with multiple sclerosis (MS) is looking for disease biomarkers that can help healthcare providers better estimate how individual cases of MS will progress. The goal of Stephanie Buxhoeveden’s research, ...