In common with other omics technologies, mass spectrometry (MS)-based proteomics produces ever-increasing amounts of raw data, making efficient analysis a principal challenge. A plethora of different computatio
Targeted proteomics, as an efficient and sensitive technology for protein identification and quantification, is dependent on the availability of custom peptides for assay development and absolute quantification. For absolute protein quantification the peptides must be heavily labeled and quantified. Current ...
MS based foodomics for multidimensional analysis The innovative approaches on sample preparation, data acquisition and processing have served as an impetus for the applications of single metabolomics, proteomics and their integrated multiomics. Especially in foodomics analysis, the implementation of multiomics...
Talk Title: Biomarker discovery and validation for liver diseases using mass spectrometry (MS)-based proteomics 讨论嘉宾: 姜颖,国家蛋白质科学中心(北京)研究员 李平,诺和诺德中国研究中心首席科学家 陆恬,西湖大学Guomics实验室博士生 郭天南,西湖大学特聘研究员,蛋白质组大数据实验室 (Guomics) 负责人,西湖实验...
organ-specific proteomic alterations of the allergy responses, the spleen and intestine of mice sensitized with high (shrimp and clam) and weak (fish) allergenic tropomyosins were analyzed using sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS)-based proteomics. ...
2 Peptide extraction Peptide extraction 10 9 processing time 8 7 gel slicing 6 Incubation time 5 4 3 2 1 0 IGD 10 WG 10 8 7 6 5 4 3 2 1 0 IGD 10 WG 10 Day 1 IGD 90 Day 2 IGD 90 WG 90 WG 90 Whole gel processing procedure for GeLC-MS/MS based proteomics Piersma et al...
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(LC-MS/MS)-based targeted proteomics approach to quantify target miRNA by innovatively converting the miRNA signal into the mass response of a reporter peptideviaa covalently immobilized DNA-peptide probe. Specifically, the probe containing the targeted proteomics-selected substrate/reporter peptide,GDR...
液相色谱-串联质谱法(LS-MS/MS)的蛋白质定量结果取决于一系列相关的参数,而参数之间的相关性对解决LS-MS/MS中的特定问题提出了挑战。DO-MS是针对于单细胞蛋白质定量过程中优化参数的工具方法,并能够诊断定量过程中出现的问题并提出相应的解决方案。这篇文章的作者团队同样也开发了基于LS-MS/MS的单细胞蛋白质定量...