Learn more from this WebMD slideshow about multiple sclerosis, MS -- its cause, symptoms, diagnosis, treatment, and other facts.
With the aim of increasing the contrast of the FLAIR MR images with respect to the MS lesions, the proposed method first estimates the fuzzy memberships of brain tissues (i.e., the cerebrospinal fluid (CSF), the normal-appearing brain tissue (NABT), and the lesion). The procedure for ...
Tissue glyco-capture (TGC), a highly sensitive MS-compatible method for extraction of glycans from tissue, was combined with structure-specific nano-LC/MS for sensitive and detailed profiling of the mouse brain glycome. Hundreds of glycan structures were directly detected by accurate mass MS and ...
The article reports that a study at the University of California, San Francisco indicated that the protein Axin2 has a crucial role in myelination, adult multiple sclerosis (MS) and hypoxia-induced white matter injury (WMI) in newborns. It explains that myelin destruction following hypoxia causes...
Multiple sclerosis attacks nerve cells in the brain and spinal cord. What are the early signs, and how can you slow progression of this disease? Secondary Symptoms Primary MS symptoms like tiredness and trouble walking or emptying your bladder happen because of nerve damage. They can lead to ...
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The symptoms of multiple sclerosis (MS), an immune-mediated, degenerative disease of the central nervous system (CNS), are thought to be due to demyelination and axonal damage leading to impairment of neurotransmission. In a mouse model ... SJ Jackson - 《University College London》 被引量: ...
Measurement of KYN metabolite levels will help elucidating the involvement of the KYN pathway in the disease pathology and inform drug development.Methodology:Samples of plasma, cerebrospinal fluid or brain tissue were spiked with deuterated internal standards, processed and analyzed by LC–MS/MS; ...
LC-MS/MS method was developed for simultaneous quantitation of quetiapine and duloxetine in rat plasma. • A one-step protein precipitation was adopted to prepare 50 μL of rat plasma. • Pharmacokinetic interaction of quetiapine and duloxetine was studied for the first time. ...
The theme for World Brain Day (WBD) this year is ‘Stopping MS’. Despite the amazing progress that science and medicine have made in the development of therapies for multiple sclerosis (MS), access to such therapies is still a major challenge in many pa