在801例MS病例中,只有1例MS病例发生在EBV阴性个体中,这些样本是在MS发病前一年收集的。 EBV阳性与EBV阴性MS的风险比(HR)为26.5。在基线检查时,34例EBV阴性MS患者在随访期间感染了EBV,35例患者均在MS发病前血清转化。EBV血清转化是最后一个...
Epstein-Barr Virus (EBV)Infectious Mononucleosis (IM)MS pathogenesisMolecular mimicryMultiple Sclerosis (MS)Multiple Sclerosis (MS) is a chronic neurological disease with genetic and environmental risk factors. Epstein Barr-Virus (EBV) has been closely associated with MS but with a significant amount ...
2022年,Alberto Ascherio团队在Science上发表研究,通过大量纵向样本数据证明了EBV感染与MS发病的关联性3;后续多个研究团队发现EBV转录因子(EBNA-1)与MS的相关性,并提出对EBNA-1的抗体反应可能是MS最强的血清学危险因素,这一发现为MS的早期诊断和预防提供了新的视角4。去年...
这 35 例 EBV 阴性 MS 病例中除 1 例在随访期间都感染了 EBV,并且在 MS 发作前均发生了血清转化(图 S3)。从第一个 EBV 阳性样本到 MS 发病的中位时间是 5 年(范围:0 到 10 年),从估计的 EBV 血清转化的中位时间,定义为最后一个血清阴性样本和第一个血清阳性样本之间的中点,到MS 发病时间为 7.5 ...
MS。病例的地理分布和其他数据表明，缺乏阳光和维生素 D 有一定作用。遗传因素至少会增加一点风险。EBV ...
Now, investigators in the U.K. and Sweden believe they might be closer to understanding how the virus, which also causes mononucleosis, might help spur MS. “The discovery of the link between Epstein-Barr Virus [EBV] and multiple sclerosis has huge implications for our understanding ...
Having identified a common set of autoantibodies, the team noted a similarity to patterns seen in common viruses like the Epstein-Barr Virus (EBV). “When we analyze healthy people using our technology, everybody looks unique, with their own fingerprint of immunological experience, like a snowfla...
Multiple sclerosis, a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus, according to a study led by Harvard T.H. Chan School of Public Healt
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