0 Kudos 3,552 SAP Managed Tags: SAP ERP, MAN Production Planning (PP) What is the difference in mrp1 & mrp2 views Know the answer? Help others by sharing your knowledge. Answer Need more details? Request clarification before answering. Comment Comments (0) ...
EE-S was not transported by either MRP1, MRP2, or MRP3. However, low concentrations of EE-S stimulated MRP2-mediated uptake of ethacrynic acid glutathione. EE-S also stimulated MRP2 and MRP3-mediated uptake of 17β-estradiol-17β-d-glucuronide. Interestingly, EE-S stimulated strongly MRP2...
The multidrug resistance proteins (MRPs) MRP1, MRP2, MRP3, MRP5 and P-glycoprotein (P-gp) act in concert with each other to give a net resultant pump function in acute myeloid leukemia (AML). The aim of the present study was to analyze the activity of these proteins, which might be...
5d; Supplementary Figs S12c and S13). As the binding patterns of colchicine and the CTRs to β-tubulin are only slightly different, this difference alone cannot likely explain why their efficacies against multidrug-resistant cancers are dramatically different. One possible explanation may be that ...
The N-terminal TMD0 is a unique feature that is found only in five of the multidrug resistance proteins (MRP1, MRP2, MRP3, MRP6, and MRP7), the sulfonylurea receptors SUR1 and SUR2, and TAP. In SUR1, SUR2, and TAP, TMD0 is known to mediate interactions between the ABC transporte...
Cell-type-specific expression and subcellular localization of MRP1 in various physiological barriers. The figure illustrates the relative position of MRP1 and other selected ABC transporters (MDR1/P-glycoprotein, ABCG2, and MRP2) at the blood–brain barrier (a), the blood–cerebrospinal fluid barr...
However, several substrates of MRP1 and MRP2, including most of the natural product drugs to which they confer resistance, are not conjugated to any significant extent in vivo, but their transport is stimulated by GSH. Current evidence suggests that at least some of these drugs are co-...
The ability of MRP1 to confer drug resistance and transport conjugated organic anions is shared by at least two other proteins belonging to the ABCC subfamily, MRP2 (ABCC2) and MRP3 (ABCC3) (5, 6). These three proteins share a common five-domain structure that distinguishes them from most...
One important difference between MRP1 and MRP2 with respect to anti-cancer drug resistance is that over-expression of MRP2, but not MRP1, is associated with cisplatin resistance. Thus, cisplatin resistance in MRP2 expressing cells is abrogated by MRP2 antisense cDNA and cells transfected with MRP2...