Dougherty J D, Reineke L C,Lloyd R E.mRNA decappingenzyme la (Dcpla)—induced translational arrest through proteinkinase R (PKR) activation requires the N-terminal enabled va-sodilator-stimulated protein homology 1 (EVH1) domain[J]. TheJournal of Biological Chemistry, 2014, 289(7): 3936-...
建议收到该mRNA-Decapping Enzyme 1B (DCP1B) Antibody产品后,储存温度为-20°C。避免重复冻融 其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELIS...
mRNA Decapping Enzyme catalyzes the removal of 7-methylguanosine cap (m7G) from 5´ end of mRNA, producing 5′ monophosphate and releasing m7GDP(1). mRNA Decapping Enzyme is capable of decapping mRNAs of various lengths and removes both Cap0 and Cap1 structures with similar efficiency. mRNA...
mRNA‑decapping enzyme 1a (DCP1a), which may be used as a marker to analyze P‑bodies, participates in the removal of the 5'‑methylguanosine cap from eukaryotic mRNAs as a cofactor. The aim of the present study was to analyze the association between DCP1a expression and clinical ...
Regulation of mRNA half-life is a crucial control point of gene expression. Removal of the protective 5' methylguanosine cap is a committed step in the 5'-3' decay pathway, which is carried out by the decapping enzyme Dpc2. Although Dcp2 is sufficient for decapping its activity is ...
enzyme from a family known as the ApaH-like phosphatases that removes the rather unusual 5´-end modification from mRNAs in trypanosomatidae, human pathogenic parasites responsible for several neglected tropical diseases. This enzyme could offer a specific therapeutic target in such parasites. It ...
1624Accesses 3Altmetric Metrics The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the...
miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation Qian Zhang, Yun-Fei Yan, Qing Lv, You-Jie Li, Ran-Ran Wang, Guang-Bin Sun, Li Pan, Jin-Xia Hu, Ning Xie, Can Zhang, Bao-Cheng Tian, Fei Jiao, Sen...
The demonstration that hDcp2 is an RNA-binding protein with an RNA-dependent decapping activity will now provide new approaches to identify specific mRNAs that are regulated by this decapping, enzyme as well as provide novel avenues to control mRNA decapping and turnover by influencing the RNA-...
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures We have cloned cDNAs for the human homologues of the yeast Dcp1 and Dcp2 factors involved in the major (5'-3') and NMD mRNA decay pathways. While yeast Dcp... EV Dijk,N Cougot,S Meyer,...