[2] Jeong D.-E., McCoy M., Artiles K., Ilbay O., Fire A., Nadeau K., Park H., Betts B., Boyd S., Hoh R., et al. Assemblies of Putative SARS-CoV2 Spike Encoding mRNA Sequences for Vaccines BNT-162b2 and mRNA-127...
开创了信使核糖核酸疗法和疫苗,为患者创造新一代的变革性药物,今天宣布了 MRNA-1273的临床数据,该公司研制的新型冠状病毒(SARS-CoV-2)候选疫苗 MRNA-1273,来自美国国家过敏与传染病研究所(NIH)领导的第一阶段研究,是 NIH 的一部分。
(A) Alignment of S protein consensus sequence, where pink and gray indicate variant amino acid position and missing sequence data, respectively. (B) Syrian hamsters (n = 10/group) were infected with 1 × 103 (gray), 1 × 104 (black), or 1 × 105 (red) dilution of JHU B.1.351...
Protection against SARS-CoV-2 replication in the airways An extensive analysis was performed to characterize the nucleotide sequence and in vivo pathogenicity. Deep sequencing was performed after each passage (P) of the B.1.351 strain, and the challenge stock retained all mutations in the RBD and...
it was shipped to NIH on February 24, 42 days from sequence selection. The first participant in the NIH-led Phase 1 study of mRNA-1273 was dosed on March 16, 63 days from sequence selection to Phase 1 study dosing....
https://iris.who.int/bitstream/handle/10665/373987/WHO-2019-nCoV-Vaccines-SAGE-Prioritization-2023.2-eng.pdf?sequence=1 Spikevax (mRNA-1273). Full prescribing information, Moderna, Inc., Cambridge, MA, 2022.
[2] Jeong D.-E., McCoy M., Artiles K., Ilbay O., Fire A., Nadeau K., Park H., Betts B., Boyd S., Hoh R., et al. Assemblies of Putative SARS-CoV2 Spike Encoding mRNA Sequences for Vaccines BNT-162b2 and mRNA-1273. ...
Additional file 2: Video 2. Cardiac MRI completed on hospital day 2 showing areas of hypokinesis and dssynchrony in distal septum and of the RV. Sequence details: SSFP technique #phase 20; flip angle 45°, slice thickness 8 mm, FOV 40 cm, TR-3.7 ms, TE-1.5 ms. ...
A sequence-optimized mRNA encoding prefusion-stabilized SARS-CoV-2 S protein containing 2 proline stabilization mutations (S-2P) (Pallesen et al., 2017; Wrapp et al., 2020) for WA1, Omicron, and Beta were synthesized in vitro and formulated (Hassett et al., 2019). Control mRNA “UNFIX-...