[26] Lamb Y N. BNT162b2 mRNA COVID-19 vaccine: fist approval[J]. Drugs, 2021, 81(4): 495-501. [27] Huang Q R, Ji K, Tian S Y, et al. A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mic...
Large-scale, randomized clinical trials are essential to validate the efficacy and safety of mRNA vaccines in GBM therapy. The potential to reshape the tumor microenvironment and establish long-term immunological memory underscores the transformative potential of mRNA vaccines in cancer immunotherapy....
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in...
She said her concerns have less to do with the use of mRNA and more to do with the long-term efficacy of the vaccine, as well as other challenges that could cause something to go wrong and lead people to believe they are vaccinated when they are not. For example, she said that becaus...
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 Qingrui Huang, Kai Ji, Siyu Tian, Fengze Wang, Baoying Huang, Zhou Tong, Shuguang Tan, Junfeng Hao, Qihui Wang, Wenjie Tan, George F. Gao & Jinghua Yan Nature Communi...
Health Alert on mRNA COVID-19 Vaccine Safety The COVID-19 pandemic brought many challenges that the health and medical field have never encountered. Although the initial response was led by a sense of urgency and crisis management, the State Surgeon General believes it is critical that as publi...
The original monovalent mRNA vaccines, authorized in June 2022, were based on immunobridging, safety, and limited efficacy data from clinical trials. Authorization of Pfizer-BioNTech’s vaccine was for children aged 6 months to 4 years, while Moderna’s was for children aged 6...
Stability is a major concern regarding the storage temperatures, as they need a typical storage temperature range of 2–8 °C and −70 °C for the long term. The design of optimally stabilized mRNA vaccine formulations during storage, transport, and administration at refrigerated or room tempera...
Long-term immunogenicity and safety of heterologous boosting with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants who had received two or three... The emerging new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) needs booster vaccination. We evaluated the ...
Our studies offer a potential solution to overcome the long-term storage-related limitations of nucleoside-modified mRNA-LNP vaccines. 展开 关键词: mRNA lipid nanoparticle nucleoside modification lyophilization vaccine DOI: 10.1016/j.ymthe.2022.02.001 年份: 2022 ...