Moderna正在评估编码融合前F蛋白的三种单剂量候选疫苗:mRNA-1172和mRNA-1777用于成人,以及mRNA-1345用于儿童。在I期临床试验中,mRNA-1777诱导RSV中和抗体产生强烈的体液反应,CD4+T细胞对RSV F蛋白产生反应,且无严重不良事件。mRNA-1345的序列已被进一步设计和密码子优化,以增强相对于mRNA-...
Moderna announced that the clinical trial of its mRNA vaccine for respiratory syncytial virus (RSV)...
参考文献: 1. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat RevDrug Discov. 2021 Aug 25 : 1–22. 2. Recent advances in mRNA vaccine technology. Curr Opin Immunol. 2020 Aug;65:14-20.
Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: Preclinical studies and Phase 1 clinical testing in healthy adults. Vaccine. 2023 Oct 20;41(44):6488-6501. [4] Wilson E, Goswami J, Baqui AH, et al. Efficacy and Safety of an...
1.Moderna Receives U.S. FDA Approval for RSV Vaccine mRESVIA(R) (http://modernatx.com) 2.Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults | New England Journal of Medicine (http://nejm.org) 3.ASCO (http://q4cdn.com) ...
Moderna的RSV疫苗获批，是mRNA技术发展史上的一个重要里程碑。它不仅为老年人群提供了新的保护，也为mRNA技术在未来疫苗开发中的应用展示了广阔前景。随着mRNA技术的不断进步，我们有理由相信，这一创新技术将在医疗健康领域发挥更加重要的作用。参考 Moderna Receives U.S. FDA Approval for RSV Vaccine mRESVIA(R)
Moderna has announced topline results for its mRNA-based vaccine against respiratory syncytial virus (RSV) infection in adults 60 years of age and older. mRNA-1345 targets the RSV fusion (F) glycoprotein and, according to the press release, is 83.7% effective at preventing lower-respiratory-...
1.Moderna Receives U.S. FDA Approval for RSV Vaccine mRESVIA(R) (modernatx.com) 2.Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults | New England Journal of Medicine (nejm.org) 3.ASCO (q4cdn.com) 4.Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab:...
目前的RSV候选疫苗主要针对高度保守的F蛋白。尽管一些候选者由于中和抗体滴度不足而未能通过临床试验,但对F蛋白构象的新发现表明,针对融合前构象接种疫苗可产生优异的中和抗体反应。这一发现有望改进未来的疫苗设计。 Moderna正在评估编码融合前F蛋白的三种单剂量候选疫苗:mRNA-1172和mRNA-1777用于成人,以及mRNA-1345用于...
“A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates”,评估LNP包封的saRNA疫苗(SMARRT.RSV.preF)的免疫原性,肌肉注射该疫苗在naïve小鼠和非人灵长类动物(NHP)中诱导RSV中和抗体及Th1偏向型细胞应答,RSV预暴露的NHP接种单剂疫苗触发剂量依赖型...