因此,科研人员也在积极探索其它免疫细胞作为治疗实体瘤的武器,包括巨噬细胞(Macrophage),巨噬细胞约占肿瘤总量的50%,往往是最先被实体瘤吸收的细胞之一,还可以通过吞噬作用选择性杀伤癌细胞。已有研究证明,在给巨噬细胞安装CAR的同时也诱导其朝着M1(M1型的巨噬细...
近日,康德赛与四川大学华西第二医院|华西妇产儿童医院李沁桐等人合作共同在Molecular Therapy Methods & Clinical Development发表文章:Macrophage manufacturing and engineering with 5’-Cap1 and N1-methylpseudouridine-modified mRNA,他们开发了一套高效的 GMP 级别治疗性巨噬细胞生产流程,并且采用 mRNA 技术成功在巨噬...
we found that levels of m6A reader YTHDF3 significantly increased (Fig.1a). We used a western blot to verify this up-regulation. During nutrient deprivation, levels of YTHDF3 greatly increased
Clinical trials such as NCT03871348, which investigated SAR441000, a mixture of mRNAs encoding IL-12, IFN-α2b, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-15sushi, as monotherapy and in combination with cemiplimab, have shown that mRNA vaccines can effectively stimulate ...
One day after resident macrophage depletion, in vivo and ex vivo bioluminescence detection was repeated 6 h after i.p. mRNA-Luc (10 µg/mouse) administration. M3 Vision was used to analyze the data. Semisupervised analysis of flow cytometry data The semisupervised analysis of flow cytometry ...
Granulocyte-macrophage colony-stimulating factor HCMV: Human cytomegalovirus HER-2: Human epidermal growth factor receptor 2 HLA: Human leukocyte antigen HNSCC: Head and neck squamous cell carcinoma HPV: Human papilloma virus hTERT: Human telomerase reverse transcriptase ...
for the ex vivo production of CAR T cells with the ability to kill tumor cells. The results suggested that this engineered exosome delivery system has great potential for converting primary T cells into CAR T cells and provides a new approach for the in vivo induction of CAR T cells [106]...
Granulocyte–macrophage colony-stimulating factor EGFR: Epidermal growth factor receptor hTERT: Human telomerase reverse transcriptase NY-ESO-1: New York Esophageal Squamous Cell Carcinoma-1 MAGE: Melanoma-associated antigen LC: Langerhans cell HLA: ...
Granulocyte-macrophage colony-stimulating factor HCMV: Human cytomegalovirus HER-2: Human epidermal growth factor receptor 2 HLA: Human leukocyte antigen HNSCC: Head and neck squamous cell carcinoma HPV: Human papilloma virus hTERT: Human telomerase reverse transcriptase ...
Macrophage–cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy. J. Nanobiotechnology 18, 92 (2020). Article CAS PubMed PubMed Central Google Scholar Rao, L. et al. Platelet–leukocyte hybrid membrane-coated immunomagnetic beads for highly efficient and...