mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune system. With regard to mRNA vaccines, researchers ...
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune system. With regard to mRNA vaccines, researchers ...
Nucleic acid vaccines based on mRNA were conceived more than three decades ago in the hope of generating safe and versatile vaccines that are easy to produce3,4. In principle, mRNA vaccines have several advantages over conventional vaccines. Unlike some viral vaccines, mRNA does not integrate into...
Lipid nanoparticles (LNPs) are mRNA formulations based on a mixture of cholesterol, ionizable and helper lipids, and PEG-derivatives [106]. Intramuscularly administered RNA-LNPs have recently gained attention, as this is the format of the first two SARS-CoV-2 vaccines to be approved, based on...
SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID-191,2,3,4,5. The dynamics of antibody-secreting plasmablasts and germinal centre B cells induced by these vaccines in humans remain unclear. Here we examined antigen-specific B cell responses in peripheral blood (n ...
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and treatment of a wide range of diseases. The recent success of the two highly efficacious mRNA vaccines produced by Moderna and Pfizer–BioNTech to protect against COVID-
[21,22]. To achieve this, mRNA-based vaccines exhibit unique advantages over other modalities. First, mRNA allows simultaneous delivery of multiple tumor antigens, making them more resistant to immunoediting and antigen loss [14,23]. Second, mRNA can readily encode for full-length tumor antigen...
Yet inequitable reliance on imported medicines by national malaria control programmes (NMCPs) in Africa may affect the supply, availability, and accessibility of the vaccines and reduce their potential public health impact on the continent. This article examines the inequity in the global pharmaceutical...
Currently, mRNA-based vaccines have received great attention and rapid development as novel and mighty fighters against various diseases including cancer. The achievement of RNA vaccines in clinical application is largely attributed to some methodological innovations including the incorporation of modified ...
The trial was anticipated by Abdullah Baqui, principal investigator for the study sites in Bangladesh to “inform the future implementation of vaccines in adults in lower-resource areas.” Based on the trial results, Moderna intends to submit for global regulatory approval in the first half of 202...