based therapeutics,including their principles,manufacture,application,effects,and shortcomings.We also highlight the importance of mRNA optimization and delivery systems in successful mRNA therapeutics and discuss the key challenges and opportunities in developing these tools into powerful and versatile tools ...
There is also a substantial challenge for mRNA delivery in vivo.212Nude mRNA is directly used for mRNA-based therapeutics; however, it is vulnerable to the widely distributed RNase in vivo. Therefore, a delivery system is essential for mRNA-based therapeutics.213Research on siRNA vectors is relat...
图源:mRNA-based therapeutics: powerful and versatile tools to combat diseases mRNA 行业现状 Guide View mRNA 技术的应用在之前一直处于不温不火的态势,新冠疫情的爆发似乎为 mRNA 疫苗技术的研发以及市场的开拓都添了一把火。 一、「国际 mRNA 三巨头」 Moderna:mRNA 领域的领军者之一,他们开发出的 COVID-19 ...
近日,来自四川大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“mRNA-based therapeutics: powerful and versatile tools to combat diseases”的综述性文章,研究者全面介绍了基于信使核糖核酸的治疗方法,包括它们的原理、制造、应用、效果和不足。 信使核糖核酸(Messenger RNA,mRNA)的治疗应用为...
3. mRNA-based therapeutics: powerful and versatile tools to combat diseases. Signal Transduct Target Ther. 2022;7(1):166. 4. mRNA药物修饰及其递送系统研究进展. 浙江大学学报. 2023 Aug 25; 52(4):439–450. 5. Evolution of the market for mRNA technology. Nat Rev Drug Discov. 2021,20(10)...
mRNA-based cancer therapeutics Article 13 June 2023 mRNA-based therapeutics: powerful and versatile tools to combat diseases Article Open access 21 May 2022 High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies Article Open access 06 July 2021 References...
[1] Qin S, Tang X, Chen Y, et al. mRNA-based therapeutics: powerful and versatile tools to combat diseases. Signal Transduct Target Ther. 2022 May 21;7(1):166. [2] Kim SC, Sekhon SS, Shin WR, et al. Modifications of mRNA ...
[3] Qin SG, Tang SH, Chen YT, et al. mRNA-based therapeutics:powerful and versatile tools to combat diseases[J]. Signal Transduct Target Ther, 2022, 7(1):166. [4] Gábor TS, Azita JM, Irena V. COVID-19 mRNA vaccines:...
原文:mRNA-based therapeutics: powerful and versatile tools to combat diseases 作者:Shugang Qin, Xiaoshan Tang, Yuting Chen, Kepan Chen, Na Fan, Wen Xiao, Qian Zheng, Guohong Li, Yuqing Teng, Min Wu & Xiangrong Song 相关阅读 mRNA疫苗--疫苗的新时代 ...
1. mRNA-based modalities for infectious disease management 2. 2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot. 3. mRNA-based therapeutics: powerful and versatile tools to combat dise...