given what you now know, you can easily envision how this happens. DNA is double-stranded, so each strand can serve as a template for single-stranded RNA; these two new RNA strands, owing to the vagaries of specific base-pairing, will be complementary to each other, not that they...
P. Mauro, "An mRNA-rRNA base- pairing mechanism for translation initiation in eukaryotes.," Nat. Struct. Mol. Biol., vol. 13, no. 1, pp. 30-4, Jan. 2006.J. Dresios, S.A. Chappell, W. Zhou, V.P. Mauro, An mRNA-rRNA base-pairing mechanism for translation initiation in ...
Base-pairing of messenger RNA to ribosomal RNA is a mechanism of translation initiation in prokaryotes. Although analogous base-pairing has been suggested to affect the translation of various eukaryotic mRNAs, direct evidence has been lacking. To test su
MiRanda (John et al., 2004) and TargetScan (Lewis et al., 2003) require different base-pairing rules, cross- species conservation to identify potential miRNA binding sties. In order to compensate for limitations of their computational target prediction programs, we simultaneously showed the results...
Using a combination of bioinformatics and mutagenesis we sought to identify the base pairing requirement for functional repression of HctA protein expression, with an eye to applying our findings towards the identification of additional targets. IhtA is predicted to fold into a three stem:loop ...
The interaction functions via antiparallel base pairing betwwen either 1 of the 2 UCA motifs in helix 34 and the complementary UGA stop codon on the message, thus forming a quasicontinuous A-type helical structure that is further stabilized by stacking enthalpy. Finally, rRNA motifs potentially ...
What areas of the molecules must follow base pairing rules to complete successful translation? Why does a cell need both mRNA and tRNA to create a protein? How do they work together? What does a cell need to carry out transcription before translation?
Why are the complementary base pairing rules so important when a cell needs to copy its DNA? A. As long as there is one strand, a copy can be made by following the pairing rules. B. The cells need both strands to be accurate because each strand code for...
The present study provides, to our knowledge, the first functional demonstration of mRNA-rRNA base pairing in mammalian cells. By contrast with other rRNA... A Wagner - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 6发表: 2013年 Optical measuremen...
with A and G residues. Therefore, the complexity of base pairing with the UUUC sequence is increased, suggesting that many other mRNAs may be assisted by the interaction with h16 in a similar way. In addition, the presence of the TWJ-folded domain locks the ribosome in a pre-translocation...