An mRNA‑rRNA base‑pairing mechanism for translation initiation in eukaryotes. Nat Struct Mol Biol 2006; 13:30‑4.Dresios J, Chappell SA, Zhou W, Mauro VP (2006) An mRNA-rRNA base-pairing mechanism for t
given what you now know, you can easily envision how this happens. DNA is double-stranded, so each strand can serve as a template for single-stranded RNA; these two new RNA strands, owing to the vagaries of specific base-pairing, will be complementary to each other, not that they...
with A and G residues. Therefore, the complexity of base pairing with the UUUC sequence is increased, suggesting that many other mRNAs may be assisted by the interaction with h16 in a similar way. In addition, the presence of the TWJ-folded domain locks the ribosome in a pre-translocation...
Codons refer to triplet base sequences in the a. mRNA. b. nontemplate strand of DNA. c. template strand of DNA. d. tRNA. e.rRNA. Which strand of DNA is used to make mRNA? What are the RNA base pairing rules? What type of RNA combines ...
What areas of the molecules must follow base pairing rules to complete successful translation? Why does a cell need both mRNA and tRNA to create a protein? How do they work together? What does a cell need to carry out transcription before translation?
A significant fraction of the long-range context effect appears to be due to base pairing between two intronic regions near the 5′ splice site and branchpoint, an interaction that positively affects splicing efficiency as well as splice site selection....
RNA structure is formed by Watson–Crick base pairing and can be further stabilized through other RNA interactions, such as sugar-backbone interactions. Structure in mRNAs can affect translation in multiple ways. First, mRNA structures can inhibit translation initiation by physically blocking the PIC ...
(GAGG) transcripts. ADP-ribosylation of Shine-Dalgarno sequences may prevent modified transcripts from engaging ribosomes and initiating translation. Alternatively, or in addition, the modification of GA dinucleotides within an mRNA may disrupt base-pairing with tRNAs or may stall ribosomal translocation...
Secondary structures tolerate substitutions that preserve base pairing in stem regions, a characteristic known as covariance. To identify conserved and thermodynamically stable RNA secondary structures using a covariance model, the seven yeast genomes were scanned with RNAz [43, 44], and a small set ...
(e.g., the percentage) of bases in opposing strands that are expected to form hydrogen bonds with each other, according to generally accepted base-pairing rules. The sequence of an oligomeric compound, e.g., an ASO, need not be 100% complementary to that of its target nucleic acid to ...