其中针对HSV的mRNA疫苗mRNA-1608已进入III期临床研究;针对VZV的mRNA-1468通过表达VZV糖蛋白e来降低带状疱疹的发病率。针对诺如病毒的多样性,Moderna开发了两款多价病毒样颗粒(VLP)疫苗mRNA-1403(三价)和mRNA-1405(五价),用于预防幼儿和老年人中最普遍的诺如病毒基因型的急性胃肠炎。目前m...
Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA m7G. Such inter
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