Locally produced oligoclonal IgG bands (OCB) are present in the cerebrospinal fluid (CSF) of 95% patients with multiple sclerosis (MS)[2,3]. The most sensitive method for the detection of OCB is isoelectric focusing (IEF) [1]. Occasional patients with clinically definite MS lack evidence ...
6.Kilsdonk ID, Jonkman LE, Klaver R, van Veluw SJ, Zwanenburg JJ, Kuijer JP, Pouwels PJ, Twisk JW, Wattjes MP, Luijten PR, Barkhof F, Geurts JJ.Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem...
将该征象在纳入诊断标准之前需要进一步的研究,包括敏感性和特异性的评估,MRI的标准化流程和建立相应的指南。 医脉通编译自:Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines. Brain. 2019 Jul; 142(7): 1858-1875. 原...
脑出血 (Brain hemorrhage):脑部的血管破裂导致的出血。 脑积水 (Hydrocephalus):由于脑脊液积聚在脑内导致的脑部肿胀。 脊髓(Spinal cord):从大脑向下延伸,位于脊椎内部,负责传送神经信息的组织。 脂肪(Fat):一种储存能量的物质,也能保护和保温。 骨折(Fracture):指的是骨骼的连续性中断,通常由于外力引起。 往期回...
6.Kilsdonk ID, Jonkman LE, Klaver R, van Veluw SJ, Zwanenburg JJ, Kuijer JP, Pouwels PJ, Twisk JW, Wattjes MP, Luijten PR, Barkhof F, Geurts JJ.Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study.Brain. 2016 May;139(Pt...
Heckova E, Dal-Bianco A, Strasser B, et al. Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis. Radiology. Published online January 4, 2022:210614. doi:10.1148/radiol.210614...
Conventional MRIDW MRIBackground: Multiple sclerosis (MS) is a chronic disease that begins most commonly in young adults and is characterized pathologically by multiple areas of central nervous system (CNS) white matter inflammation, demyelination, and glial scarring. The most valuable aid for ...
We aimed to assess differences in resting-state functional connectivity (FC) between distinct morphological MRI-phenotypes in multiple sclerosis (MS). Out of 180 MS patients, we identified those with high T2-hyperintense lesion load (T2-LL) and high normalized brain volume (NBV; a predominately ...
[23]Vargas WS, Monohan E, Pandya S, et al. Measuring longitudinal myelin waterfraction in new multiple sclerosis lesions. Neuroimage Clin, 2015, 9: 369-375. [24]Kolind S, Seddigh A, Combes A, et al. Brain and cord myelin water imaging...
Confort-Gouny, S., Pelletier, J., Achard, S., Ranjeva, J.-P., Audoin, B., 2016. Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: a longitudinal restingstate fMRI study. Mult. Scler. 22, 1695-1708.https://doi.org/10.1177/13524585...