Maintenance therapy cessation for three-year sustained MRD negative multiple myeloma patients. Presented at: 21st International Myeloma Society Annual Meeting; September 25-28, 2024; Rio De Janeiro, Brazil. Abstract OA-15. 2. Stopping maintenance therapy in people with multiple myeloma in MRD-...
MRD-negative Status Linked With Better Survival in Multiple MyelomaStephen Cho
英文标题:Maintenance Therapy Cessation for Sustained MRD Negative Multiple Myeloma Patients 中文标题:持续MRD阴性的MM患者停止维持治疗 摘要号:992 Session:902. Health Services and Quality—Lymphoid Malignancies: Time for Change: Health ...
In the experimental arm, 48.7% of patients maintained MRD negativity at a 10-5 sensitivity for at least 12 months, and 30.3% remained MRD negative at the 10-6 threshold for at least 12 months. Those respective rates were 25.6% and 14.1% in the control arm. D-VRd (n = 44) also...
s what they were doing. I was a bit like you, Natalie. I was waiting till there was a decision point to be made, like Tom said. Maybe they’re getting toxicity from maintenance, and you’re probably looking for an excuse to take them off if they’re MRD negative on a couple of ...
With an MRD positive test, there are still cancer cells present whereas with an MRD negative result, there are no cancer cells present, which has been correlated with longer remission periods and improved survival rates[8]. Levels of MRD can be measured in several different ways and often depe...
2020年7月,美国印第安纳大学研究团队于JAMA Oncology杂志在线发表了题为“Association of Circulating Tumor DNA and Circulating Tumor Cells After Neoadjuvant Chemotherapy With Disease Recurrence in Patients With Triple-Negative Breast Cancer”的论文,研究表明将ctDNA测序和CTCs计数结合起来的新方法可以检测出女性TNBC...
Clinical end points stratified by MRD status (positive or negative) were extracted, including hazard ratios (HRs) on PFS and OS, P values, and confidence intervals (CIs). HRs were estimated based on reconstructed patient-level data from published Kaplan-Meier curves. Forty-four eligible studies ...
including relapse prediction. When tracking multiple clonotype sequences, it is important to consider the type of gene rearrangement being tracked. A check of the tracking sequence in a negative control is also necessary to ensure that it is not a part of the polyclonal background, which could ...
Very few of my patients are MRD negative before transplant. We use it in that sense. I try not to use it to say whether we’re going to transplant. But I use any tool that can help them look at it.For maintenance, we have a couple of trials. If you’re MRD positive, you ...