Mutations in MC4R are the most common cause of monogenic obesity and can affect multiple signaling pathways including Gs-cAMP, Gq, ERK1/2, 尾-arrestin recruitment, internalization and cell surface expression. The melanocortin-2 receptor accessory protein 2 (MRAP2), is a single-pass transmembrane...
目前研究黑色素皮质激素系统的调节主要集中在研究黑皮质素-3受体(MC3R),黑皮质素-4受体(MC4R)和黑皮质素-2受体辅助蛋白2(MRAP2).MC4R敲除后的小鼠会过度摄食,... 靳宣宣 - 同济大学 被引量: 0发表: 0年 罗非鱼MC4R基因克隆及与其生长相关的SNPs位点 黑素皮质素受体-4(Melanocortin receptor-4,MC4R)是5种...
MRAP2 has previously been shown to potentiate MC4R signaling to promote leanness10, 11 and to inhibit the PKR112, an anorexigenic GPCR expressed in POMC neurons20. This new role of MRAP2 in the ARC further establishes the importance of MRAP2 in the regulation of energy homeostasis by the...
Mutations in MC4R are the single most common cause of monogenic obesity. Investigating the way in which these receptors signal and traffic to the cell membrane is vital in understanding disease processes related to MCR dysfunction. MRAP is an MC2R accessory protein, responsible for adrenal MC2R ...
The cloned grouper MC4R was functional, exhibiting high constitutive activity in cAMP pathway, capable of binding to three peptide agonists and increasing intracellular cAMP production dose-dependently. MRAP2 significantly decreased basal and agonist-stimulated cAMP signaling. MRAP2 also increased basal ...
Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic neurons that modulate the function of appetite-regulating receptors, including melanocortin-4 receptor (MC4R) and growth hormone secretagogue receptor (GHSR). While pathogenic variants in the M...
Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake. By demonstrating that MRAP2 modulates the activity of OX1R we further establish the critical role of MRAP2 in the control of energy homeostasis. 展开 关键词: Receptor regulation ...
Naturally Occurring Mutations in the Melanocortin Receptor Accesory Protein 2 (MRAP2) Disturb Melanocortin 4 Receptor (MC4R) FunctionHeike Biebermann
MC4RMC5RmelanocortinACTHMelanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and influences the expression, localisation, signalling and internalisation of the melanocortin receptor 2 (MC2); the adrenocorticotropic hormone (ACTH) receptor. Mutations in MRAP are associated with ...