While pathogenic variants in the MRAP2 gene are associated with obesity, the mechanism for this remains unclear. The aim of this study is to investigate the functional impact of wildtype (WT) MRAP2 and MRAP2 variants on MC4R and GHSR signaling. Four MRAP2 variants (S80F, R125C, P167...
Monogenic forms of obesity are caused by single-gene variants which affect the energy homeostasis by increasing food intake and decreasing energy expenditure. Most of these variants result from disruption of the leptin鈥搈elanocortin signaling, which can cause severe early-onset obesity and hyperphagia...
MRAP2 重组腺相关病毒 货号产品名称Method规格价格货期 CDS-M05754-8rAAV-MRAP2重组过表达腺相关病毒10^12 vg/支￥25002-3周 CDS-M05754-9rAAV-sh-MRAP2重组干扰腺相关病毒10^12 vg/支￥25002-3周 CDS-M05754-10rAAV-mir30-sh-MRAP2重组mir30干扰腺相关病毒10^12 vg/支￥25002-3周 ...
Whereas fasting resulted in a significant increase in Agrp and Npy gene expression in WT animals, this was not the case in Mrap2 KO animals (Fig. 2f–i). Interestingly, the deletion of MRAP2 does not only affect AGRP neurons but also proopiomelanocortin (POMC) neurons since the decrease ...
•First genome-wide microarray analysis of 6q14.1–6q16.3 in 109 PWL patients•Mutation analysis ofSIM1andMRAP2in 94 PWL patients•No gene harboring deletions were identified in the 6q14.1–6q16.3 region.•Identification of first rareMRAP2variation, p.A40S, in a PWL patient•A not ...
华硕研扬发布 GENE-RAP6 迷你板：双千兆、双内存/M.2 SSD 华硕旗下研扬科技发布了一款小尺寸主板（单片主计算机）——GENE-RAP6，只有3.5英寸，基于英特尔最新第13代平台，扩展还不错。巴掌大，基于SBC 3.5英寸板型，尺寸为146×101.7mm，重量为430g。由于空间有限，所以正反面秘密密密麻麻的。处理器位于...
如果需要确认某一种siRNA单独沉默Rap 2C基因效果,可以申请单独购买某种siRNA双链。 适合的对照抗体:Rap 2A/B/C: sc-515711 同时提供sqRT-PCR 引物: Rap 2C (m)-PR: sc-152699-PR, 20 µl 获取si/shRNA 基因沉默子的详细信息 看到协议线上. ...
Dj Kilos、MC Gene、RapNow - Soy
Gi Wook HwangSeong Eun OhTsutomu TakahashiJin Yong LeeAkira NaganumaJournal of contemporary psychotherapyHwang GW, Oh SE, Takahashi T, Lee JY, Naganuma A 2010 siRNA-mediated knockdown of the melanocortin 2 receptor acces- sory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK...
Recently, potential modulators of endometrial receptivity (OVGP1, MRAP2, ZCCHC12, and HAP1) have been reported likely with a functional role during embryo implantation. The aim of this study was to evaluate the gene expression of these genes in the endometrium of infertile women.D'Aurora, ...