(2)多效性检验 (Pleiotropy test):主要检验多个IV是否存在水平多效性,常用MR Egger法的截距项表示,如果该截距项与0差异很大,说明存在水平多效性。除此以外,MR-PRESSO包也是常用的检验水平多效性的R包。 (3)逐个剔除检验 (Leave-one-out sensitivity test):主要是逐个剔除IV后计算剩下IV的MR结果,如果剔除某个...
Egger估计是唯一一条不会自动穿过原点的直线。 Leave-one-out analysis Leave-one-out analysis: Leave-one-out sensitivity analysis is performed to ascertain if an association is being disproportionately influenced by a single SNP. Each black point in the forest plot represents the MR analysis (using ...
「留一分析(Leave-one-out analysis)」 # 执行留一分析,其中MR为 再次执行,但依次省略每个SNP,以确定是否 单个SNP正在推动这种关联。res_loo <- mr_leaveoneout(dat)## 森林图p3 <- mr_leaveoneout_plot(res_loo)p3[[1]]## 漏斗图p4 <- mr_funnel_plot(res_single)p4[[1]] 结果展示(部分): exp...
首先推荐使用“MR-PRESSO”包(后面我会简单介绍它的使用情况)来检测outliers是否存在,一旦存在,剔除outliers,然后进行下面的分析。当然,大家也可以使用leave-one-out sensitivity analysis的方法剔除outliers,但我个人更倾向于”MR-PRESSO“方法。 MR方法选择三大原则: (1)在没有异质性和多效性的情况下,优先使用IVW的...
当然,大家也可以使用leave-one-out sensitivity analysis的方法剔除outliers,但我个人更倾向于”MR-PRESSO“方法。 MR方法选择三大原则: (1)在没有异质性和多效性的情况下,优先使用IVW的估计结果; (2)只有异质性,没有多效性时,优先使用Weighted Median方法的结果(也可以使用IVW的随机效应模型); (3)有多效性...
代码里的b_out表示结局的beta值,b_exp表示暴露的beta值,se_out就是结局的标准误,se_out^2就代表结局beta值的方差,而模型中的-1表示的就是去除截距项。 MR-Egger多加了截距项,其主要目的是判断水平多效性的有无;另外它也使用结局方差(se的二次方)的倒数作为权重来进行拟合,具体的R语言代码如下: ...
res_loo <- mr_leaveoneout(H_data) plot3 <- mr_leaveoneout_plot(res_loo) plot3 ``` Finally, we can produce a funnel plot for assessing heterogeneity: ```{r warning=F, message=F,results="hide"} plot4 <- mr_funnel_plot(res_single) plot4 ``` Recall that in the case of the ...
(2010), six different conditions to predict the final tissue outcome by training an ANN and testing it using the leave-one-out approach were defined. Spatial infarction incidence map and nearest-neighborhood information were fed into the model to guide the training process. The model prediction ...
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MR estimations like IVW,weighted median, MR-Egger,RAPS,and so on; Sensitivity analysis like Cochran Q test(异质性检测),Egger-intercept test(多效性检测), leave-one-out analysis Risk factor analysis Power analysis(推荐达到80%) 3.Result(呈现方法的结果) ...