SH-SY5Y cellsHuman neuroblastoma SH-SY5Y cells treated with 1-methyl-4-phenyl-pyridinium (MPP+) have been utilized as a cell model for Parkinson's disease (PD) because they mimic many aspects of the neuronal death observed in PD. Apomorphine hydrochloride (APO) is a non-selective dopamine (...
Objective To observe the effects of IL-6 on the survival and the expression of extracellular regulated protein kinases ( pERK) of SH-SY5Y cells treated by ... 李学忠,陈强,沈卉君,... - 《江苏医药》 被引量: 0发表: 2012年 丁苯酞对MPP+诱导的SH-SY5Y细胞凋亡的保护作用及机制 目的探讨丁苯酞...
Meanwhile, the levels of DMT1 were increased significantly by 2.03-fold in MPP+-treated SH-SY5Y cells, compared with that of the parkin-NS group (Fig. 4a,c, P = 0.0027). When L-NNA was add, the levels of S-nitrosylated parkin and DMT1 recovered (Fig. 5). Figure 4 GSNO and...
方法培养SH-SY5Y细胞,将其分为对照组、MPP+组、小檗碱(BBR,DMB的前...展开更多 Objective To investigate the effects of demethyleneberberine(DMB)on the mitochondrial caspase-dependent apoptosis pathway in SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium(MPP+).Methods SH-SY5Y cells were cultured...
factor-1 (HSF1), were measured byWestern blot. The melatonin effect through HSP70 was tested with silencing of HSF1 in the MPP + -treated SH-SY5Y cells.Melatonincan protect against MPP + -induced neuronal toxicity by promoting anti-oxidative and anti-apoptotic properties. SH-SY5Y cells ...
【关键词】原人参三醇组皂苷;人参皂苷.Re;SH.SY5Y细胞;帕金森病;神经保护【中图分类号】R965【文献标识码】A文章编号:2095.1396(2011)050001—007ProtectiveEffectOfPPTandGinsenoside.ReinMPP+-treatedSH.SY5YCellsLIDong-wei,DOUDe—qiangCollegeofPharmacy,LiaoningUniversityofTraditionalChineseMedicine,Dalian,116620,...
LUHMES cells, on the other hand, did not show significant differences between growth conditions for any of the toxicants examined. However, LUHMES cells were more sensitive to MPP+, tunicamycin and epoxomicin than SH㏒Y5Y cells. Thus, both the choice of cell line and the choice of growth ...
Sal increases cell viability in MPP+-treated SH-SY5Y cells To evaluate the toxicity of MPP+, SH-SY5Y cells were treated with different concentrations of MPP+(0.1 mM, 0.3 mM, 0.5 mM, 1 mM, and 5 mM) for different time (24 h, 36 h, and 48 h); cell viability was subsequently measur...
It has been reported that GRP78 was up-regulated in MPP+ treated cells and MPTP-treated PD mice model (Cai et al., 2017). Meanwhile, CHOP and cleaved caspase-12, two main proteins of ERS-mediated apoptosis, were increased in MPP+ treated SH-SY5Y cells (Jiang et al., 2018). Show ...
Methods SH-SY5Y cells were treated with MPP+(0. 25, 0. 5, 1 and 2 mmol / L for 24 hours) and LBP ( 50, 100, 200 and 400 μg / mL Lycium barbarum polysaccharide pretreatment for 1 hour and then treated with MPP+ for 24 hours) . ...