两种血清型的AAV中肺受累的频率相似,但是本质上不同,MPO-AAV中更常见的是纤维性病变,而PR3-AAV中更多见的是空泡样病变。胸片上结节和肿块在PR3-AAV中更多见,斑片状浸润在MPO-AAV中更多见。开始报道肺出血在MPO-AAV中更多见,但最近的研究报道肺出血在...
Compared with the control group, the glomeruli in the MPO-AAV group had different degrees of damage, infiltration of inflammatory cell, and membrane cell hyperplasia and renal tubule edema. Compared with the control group, rats in the MPO-AAV group had significantly higher levels of FKN in ...
不同维持期治疗疗程对长期稳定缓解的MPO-AAV患者预后的影响背景:国内外指南推荐,MPO-ANCA相关性血管炎(MPO-AAV)患者经诱导期治疗获得缓解后,应予以维持期治疗以减少和预防复发.但目前对于MPO-AAV患者维持期治疗最佳疗程仍存在争议.因此,本研究拟探讨不同维持期治疗疗程对于长期稳定缓解的MPO-AAV患者疾病复发情况,...
目的 分析髓过氧化物酶阳性的抗中性粒细胞胞浆抗体相关性血管炎(myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis,MPO-AAV)患者临床特点并探讨肺部受累患者呼吸衰竭,肺部感染和死亡的危险因素.方法 收集复旦大学附属中山医院2005年2月至2013年12月初诊入院的MPO-AAV患者基线时临床资料,截至2014年8...
抗中性粒细胞胞浆抗体相关性血管炎(ANCA-associated vasculitis,AAV)主要靶抗原有:A.抗髓过氧化物酶(MPO)抗体B.抗蛋白酶3(PR3)抗体C.A和BD.抗肾小球基底膜(GBM)抗体搜索 题目 抗中性粒细胞胞浆抗体相关性血管炎(ANCA-associated vasculitis,AAV)主要靶抗原有: A.抗髓过氧化物酶(MPO)抗体B.抗蛋白酶3(PR3)...
目的 探讨MPO-AAV患者MPO,Ba和Cp表达变化及意义.方法 纳入60名初诊未治MPO-AAV患者为病例组,60名性别,年龄匹配的健康人为对照组,ELASE法测定两组血清MPO,Ba,Cp水平,伯明翰血管炎活动性评分表评分,分析病例组各检测指标间及与BVAS相关性.结果 病例组中血清MPO,Ba,Cp水平显著高于对照组,分别为[(420. 85 ± ...
The article offers information on myeloperoxidase (MPO)-anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (MPO-AAV), the role of the novel anti-moesin autoantibody along with MPO-specific ANCA, in the pathology of the disease.Carney...
Although PMA-stimulated HRGEC were damaged in the presence of neutrophils, HRGEC without PMA stimulation were not damaged.ConclusionsNeutrophils from pre-treatment MPO-AAV patients released different type of fiber-like NETs and the amount of fiber-like NETs correlated with the activity of AAV. HRG...
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCarney EF.doi:10.1038/nrneph.2013.277CarneyEllen F.Nature Reviews NephrologyCarney EF. Vasculitis: potential role of an anti-moesin autoantibody in MPO-AAV. Nat Rev Nephrol. 2014;10(2):65....