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ImmortalizedmPDLcells were kindly provided by Professor Dr. mPDLcells were cultured in 6-well plates (3 x [10.sup.5] cells/well) and stimulated with either 1 [micro]g/mL Escherichia coli LPS (Sigma-Aldrich, St. Total RNA was extracted frommPDLcells using trizol reagent, according to the...
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延迟线数控LC网络MPDL0802雷达本文论述了8位数控延迟线的设计原理,电路框图和采用的工艺,研究过程中解决的技术难点,其中包括8位数控延迟线的设计、延迟网络的设计、延迟量的调整、环境温度对延迟量的影响等。给出了解决这些问题的措施以及还存在的问题。丁宝焕混合微电子技术...
摘要:罗氏基因泰克的首席医疗官SandraHorning表示,PD-L1表达越高,获益越大,这一结果令人兴奋,这也是他们一直努力将MPDL3280A应用于临床的原因。 一项罗氏免疫治疗药物的中期临床研究表明,MPDL3280A能加倍延长高表达特异生物标志物肺癌患者的生存期。(自Medscape网) ...
罗氏(Roche)近日公布了实验性抗癌免疫疗法MPDL3280A(抗PDL1)I期开放标签研究的数据。结果表明,经MPDL3280A治疗后,有43%(13/30)的转移性尿路上皮膀胱癌( UBC)患者的肿瘤体积显著缩小,这些患者的肿瘤经罗氏开发的一款试剂盒证实为PD-L1(程序性死亡配体-1)阳性。研究中,不良事件与既往报道一致。
罗氏试验性免疫治疗药物的一项中期试验显示,它可能使带有一种高水平特定生物标志物肺癌患者的生存期加倍。这款药物的代码为MPDL3280A,它是一种新类型的药物,其旨在通过阻断一种叫程序死亡受体(PD-1)或一种相关靶点(PD-L1)的蛋白以帮助人体免疫系统抵御癌症,因为PD-1或PD-L1可被肿瘤用来逃避人体的防御。
MPDL3280A,它保留了PD-L2/ PD-1相互作用,潜在减少自身免疫性肺毒性,对晚期NSCLC有很好的疗效。以铂类为基础的化疗仍然是标准的非小细胞肺癌的一线治疗,历史总体无进展生存率约30%。临床前数据表明,化疗可能促使肿瘤抗原的释放和增强MPDL3280A活性。因此,我们研究MPDL3280A+化疗治疗未经过化疗的非小细胞肺癌患者。
A lightweight research data repository. Contribute to MPDL/imeji development by creating an account on GitHub.
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