The qRT-PCR results showed that the mRNA expressions of Jun, Wif1, Axin2, Ctnnb1, Dkk2, Notum, Nkd1, Fzd10 and Wnt16 were significantly up-regulated in the AOM/DSS group compared with the Control and PZH groups, while PZH treatment significantly down-regulated these mRNA expressions (...
Support for this idea was available in the original HBM publication describing the LRP5 activating mutation, which in cells eliminated the inhibitory actions of DKK1.130 The key role of WNT signaling in bone prompted us to examine KO mice for all four Dkks, five Sfrps and Wif1 (Table 3)....
Without confirmation in additional cohorts of mice, phenotypes identified in HTS can represent false positive findings due to the necessity of examining multiple bone parameters in a small number of mice. Bone HTS results reported by three groups all limited their analyses to primary radiographic and ...
Based on the results of epitope mapping, binding affinity, and biological functions in tumor inhibition, eight antibodies were chosen to examine their abilities in tumor regression in a mouse xenograft model using human COLO 205 cancer cells. Three of them showed improvement in the inhibition of ...