Mouse Tibialis Anterior Muscle Mass and Androgen Receptor (AR) expression with Testosterone Manipulationdoi:10.1249/01.mss.0000273842.51246.feJim P. WhiteRaymond W. ThompsonTyrone A. WashingtonKristen A. BaltgalvisJames A. CarsonOvid Technologies (Wolters Kluwer Health)Medicine & Science in Spo...
Previous research has shown that dorsiflexion immobilization results in significant muscle atrophy of tibialis anterior (TA) due to an increase in inflammation and polyubiquitylation. Therefore, the present study examined whether TA muscles from the tenotimized leg would also display significant muscle ...
Overexpression of TRB3 in mouse tibialis anterior muscle significantly impaired insulin-stimulated IRS1 Y612 (46%) and Akt T308 (23%) phosphorylation. Consistent with these findings, TRB3KO mice fed a high-fat diet for 8 weeks exerted improved insulin signaling, including IRS1 Y612 (30%), ...
Muscular dystrophy (MD) refers to a clinically and genetically heterogeneous group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. Although the primary defect underlying most forms of MD typically results from a loss of sarcolemmal integrity, the seco...
tibialis anterior musclefinite element modelviscoelasticityMolecular dynamics simulation of the 180213 segment, forming the B and C helices in the mouse prion protein, and of three mutants, where the capping box residues or the hydrophobic staple motif residues were selectively mutated, have been ...
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We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin-3, the chief protein in muscle caveolae, and reduced levels of neuronal nitric oxide synthase, an enzyme regulated by caveolin-3. Similar changes occurred in the corresponding mRNA levels. These data ...
5a, b). We also assessed NMJs of the tibialis anterior (TA) muscle, which comprised primarily of fast-twitch muscle fibers innervated by α-motor neurons of the lower lumbar spinal cord and are found to be more susceptible to disease1,4,45. Intriguingly, Matr3S85C/S85C mice showed a ...
1. b Cross section of tibialis anterior (TA) muscle stained for Cas9/GFP (green), tdTomato (magenta), and DAPI (blue), 6 weeks after injection of neuraminidase plus AAV9-sgNT or AAV9-3sgPKCα-1. c Quantification of AAV genomes per nucleus in TA muscle, heart, and liver in AAV9-...
Inmdxmice, mRK35 significantly increased body weight, muscle weights, grip strength, and ex vivo force production in the extensor digitorum longus (EDL) muscle. Further, tibialis anterior (TA) fiber size was significantly increased. NHPs treated with domagrozumab demonstrated a dose-dependent ...