ATRX recruits the death domain-associated protein (DAXX), forming a nuclear chaperone complex that promotes the incorporation of the histone variant H3.3 into telomeric and pericentromeric heterochromatin [7–9]. This deposition resolves the accumulation of G- and C-rich repeats that could compromise...
22001166,, 1177,, 111199 22ofof1212 wO(OlfarmcouPrrsJpm(afipciillteNaeeeorebssemrRAaHsehmvnmicprrgseelalnvvittcuIqOtooaaaeendPtahEiponHitoeseDihuornna/lnmmoig/ArMiloKsslrPIifndnrysde3ddsgtIPHrnNnsc.uHrcooen.rR-snTlibrOeesstreaGa2aoahnstarttGoAaiotcs,r3ireere9npnatmt)rcaomuoenveAmfoe)epi...
2.7. Statistics Data were analyzed using GraphPad Prism version 5.1 software and presented as mean +/− standard error of the mean (SEM). For in vivo experiments, five animals per group were utilized. One-way analysis of variance (ANOVA) was used to determine the statistical significance, ...