Here, ACh suppresses innate immune mechanisms by activating alpha7 nicotinic receptors expressed by macrophages and other innate immune cells to inhibit the production of pro-inflammatory cytokines including TNF-α and IL-1β (Pavlov and Tracey, 2005; Wang et al., 2004; Zdanowski et al., 2015...
This mutation can revert due to homologous recombination between the 5′ and 3′ LTR of the full length provirus, leaving a solitary LTR at the locus [136]. Phenotypic reversion by this mechanism also occurs for the hairless mutation (Hrhr), another of the first documented cases caused by ...
Viability and proliferation were evaluated using the MTT assay, which may be a more sensitive method for assessing osteoblast pro- liferation because it measures cell viability via the determination of mitochondrial dehydrogenase activity.25 The proliferation of MC3T3- E1 cells reached its peak when ...
The inbred C57BL/6 mouse strain was established at the Jackson Laboratory from the parental strain C57BL at F24 in 1948. In 1951, at F32, it was then passed on to the National Institutes of Health (NIH), leading to the C57BL/6N line. The C57BL/6NTac sub-strain was established at ...
Results Strontium oscillations are not mediated by TRPV3 channel in GV oocytes. Exposure to Sr2+ pro- motes oscillations in both GV oocytes and MII eggs26. Nevertheless, in mice, eggs lacking TRPV3 channels are unable to mount Sr2+-induced oscillations and undergo egg activation, confirming...
mouse anti-p63 Novus Biologicals Novus Cat# NB 100-691; RRID: AB_525968 rabbit anti-MVH Abcam Abcam Cat# ab13840; RRID: AB_443012 rabbit anti-RAD51 Chip-Grade Abcam Abcam Cat# ab176458; RRID: AB_2665405 mouse anti-SYCP3 Abcam Abcam Cat# ab97672; RRID: AB_10678841 guinea pig anti-HO...
methods [22–24] and the completion of the mouse genome sequence has allowed for complete characterization of the ERVs carried by the C57BL mouse [25]. ERV locations are, however, strain or strain-lineage specific; the various inbred strains carry multiple non-allelic provirus insertions [24...
[135]. This mutation can revert due to homologous recombination between the 5′ and 3′ LTR of the full length provirus, leaving a solitary LTR at the locus [136]. Phenotypic reversion by this mechanism also occurs for the hairless mutation (Hrhr), another of the first documented cases ...
www.nature.com/scientificreports OPEN Osmotin attenuates amyloid beta- induced memory impairment, tau phosphorylation and received: 30 October 2013 accepted: 01 June 2015 Published: 29 June 2015 neurodegeneration in the mouse hippocampus Tahir Ali, Gwang Ho Yoon, Shahid Ali Shah, Hae ...
Tong and Z. Sayyid for excellent technical assistance; M. Taketo for sharing the Catnb-flox(exon3) mouse, E. Rubel for sharing the Pou4f3-DTR mouse, H. Bellen for sharing antibodies; and E. Monzack for figure illustration (5 h). This work was supported by NIH-NCATS-CTSA (UL1 TR...